Condition

Anterior Cruciate Ligament Reconstruction clinical trials and research

• 20Clinical trials
• 6NIH research projects
• 11Countries

Newest Anterior Cruciate Ligament Reconstruction clinical trials

All recruiting trials (20)

• Analgesic effects of adding BiFeS block to adductor canal block after ACL reconstruction

  This study tests whether adding a BiFeS block to the standard adductor canal block provides better pain relief after ACL reconstruction.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07859397

• Donor ankle sensorimotor recovery after ACL reconstruction with a peroneus longus graft

  This study tests how the donor ankle recovers sensorimotor function after ACL reconstruction using a peroneus longus tendon autograft in adults 18–55.

  Recruiting Gazi University · Çankaya, Ankara · NCT07762989

• ACL Tear: Reconstruction vs Primary Repair outcomes after surgery

  This study tests how patients who had ACL reconstruction compare with those who had arthroscopic primary ACL repair in terms of strength, endurance, fatigue, knee stability, and function after surgery.

  Recruiting Gazi University · Ankara, Çankaya · NCT07318272

• Fractal versus steady visual walking cues after ACL reconstruction

  This tests whether fractal (variable) visual walking cues or steady metronome-like cues help athletes who had ACL reconstruction walk with steadier, safer patterns.

  Recruiting Egas Moniz - Cooperativa de Ensino Superior, CRL · Almada, Monte de Caparica · NCT07243535

• Brain-computer visualization training to improve muscle activation after orthopedic surgery

  This tests whether adding EEG-based neurofeedback visualization to usual physical therapy helps adults recovering from ACL, hip, or knee surgery activate their muscles better and speed recovery.

  Recruiting Phase 2 Rush University Medical Center · Chicago, Illinois · NCT07020312

• Eccentric training for rehabilitation after ACL surgery

  This study is testing if a special type of exercise called eccentric training helps people recover better after ACL surgery compared to regular rehab exercises.

  Recruiting Federal University of Health Science of Porto Alegre · Veranópolis, Rio Grande do Sul and 1 other locations · NCT06905691

• Using mental imagery to boost leg strength after knee surgery

  This study is testing if mental imagery exercises can help people recover and strengthen their leg after knee surgery.

  Recruiting Marquette University · Milwaukee, Wisconsin · NCT06858293

• Tourniquet versus dual-flow arthroscopy sheath for ACL reconstruction

  This trial will test whether using a dual-flow arthroscopy sheath instead of a thigh tourniquet during ACL reconstruction reduces postoperative pain and complications in adults having primary ACL surgery.

  Recruiting at 2 sites Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Reims, Marne and 2 other locations · NCT06819696

• ACL reconstruction using your own knee fat–derived stem cells

  This will try a single injection of your own mesenchymal stem cells taken from the fat under the kneecap to see if it is safe and helps recovery after ACL reconstruction with a patellar tendon autograft.

  Recruiting Phase 1 The Methodist Hospital Research Institute · Houston, Texas · NCT06798623

• Comparing two types of nerve blocks for knee surgery in children

  This study is testing which type of nerve block works better for pain relief in children aged 8-18 having knee surgery for ligament repairs.

  Recruiting Phase 4 Hospital for Special Surgery, New York · New York, New York · NCT06590402

• Evaluating the impact of proprioception and muscle strength on fear of movement after ACL reconstruction

  This study looks at how balance and muscle strength affect fear of movement in people recovering from ACL surgery to help improve their rehabilitation.

  Recruiting Bezmialem Vakif University · Istanbul · NCT06538792

• Using hyperbaric oxygen therapy to speed up recovery after ACL surgery

  This study is testing if hyperbaric oxygen therapy can help athletes recover faster after ACL surgery.

  Recruiting Assaf-Harofeh Medical Center · Zrifin · NCT06493851

• Effect of PEMF on recovery after ACL reconstruction with hamstring autograft

  This study is testing if pulsed electromagnetic field therapy can help people recover faster and regain strength in their hamstring after ACL surgery using their own hamstring tendon.

  Recruiting Chinese University of Hong Kong · Shatin · NCT06464705

• ACL reconstruction using a human cortical bone (Shark Screw®) versus a biocomposite interference screw

  This trial will test whether using a human cortical bone screw (Shark Screw®) instead of a biocomposite interference screw reduces tunnel widening and keeps re-rupture rates low for people having ACL reconstruction.

  Recruiting Bezirkskrankenhaus Schwaz · Schwaz, Tyrol · NCT06357091

• Comparing single-bundle and double-bundle ACL reconstruction techniques

  This study is testing which surgical technique, single-bundle or double-bundle ACL reconstruction, works better for people with ACL injuries.

  Recruiting Chang Gung Memorial Hospital · Taoyuan, taoyuan · NCT06341192

• Evaluating electrical stimulation methods after ACL reconstruction

  This study is testing whether combining electrical stimulation with voluntary muscle contractions helps people recover better after knee surgery compared to just using electrical stimulation alone.

  Recruiting Federal University of Health Science of Porto Alegre · Veranópolis, Rio Grande do Sul and 1 other locations · NCT06259968

• Cognitive dual-task training for athletes recovering from ACL surgery

  This study tests if adding brain exercises to physical therapy helps athletes recover better after ACL surgery and reduces the chance of getting hurt again.

  Recruiting University Ghent · Roeselare, West-Vlaanderen · NCT06206200

• Evaluating blood flow restriction training for ACL reconstruction recovery

  This study is testing whether a new kind of light exercise with blood flow restriction can help people recover better after ACL surgery compared to traditional heavy lifting.

  Recruiting Zuyderland Medisch Centrum · Sittard, Limburg · NCT05972876

• Evaluating walking patterns after ACL reconstruction

  This study is testing if different walking patterns can help people recover better after ACL surgery by looking at how their knees are loaded while walking.

  Recruiting University of Connecticut · Storrs, Connecticut · NCT05968729

• Effects of Tranexamic Acid on Joint Health After ACL Injury

  This study is testing whether Tranexamic Acid can help young adults with ACL injuries have better joint health and reduce inflammation after their injury.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT03552705

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Localized delivery to boost tendon-to-bone healing after ACL reconstruction

  A study testing a targeted small-molecule treatment to improve how the tendon graft heals at the bone after ACL reconstruction, with the goal of reducing graft failure and helping patients get back to activity.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11361627

• Split-belt treadmill training to restore knee loading after ACL surgery

  This project uses split-belt treadmill walking to help people who had ACL reconstruction regain more normal loading on their repaired knee during everyday activities.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11266154

• Local zinc delivery plus controlled loading to help bone and tendon-to-bone healing after fractures or ACL surgery

  Seeing if putting zinc directly at a healing bone site combined with controlled mechanical loading can help bones and tendon-to-bone connections heal faster and stronger for people with fractures or after ACL repair.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11250194

• Improving healing after ACL surgery with targeted medicine

  This work explores how a special medicine delivered directly to the knee might help tendons heal better to bone after ACL reconstruction surgery.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11178693

• Improving knee function after ACL surgery using a special treadmill technique

  This study is looking at how walking on a special treadmill, where each leg moves at different speeds, can help people recover better after ACL surgery by improving knee strength and movement, and it’s designed for those who have had this surgery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11035197

• Improving tendon-to-bone healing after ACL surgery

  This study is looking at a new way to help your knee heal better after ACL surgery by using special treatments right where the tendon connects to the bone, which could make recovery faster and reduce the chances of problems later on.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10978736

Related topics

Quick answers

How many Anterior Cruciate Ligament Reconstruction clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (6 trials), Turkey (Türkiye) (4 trials), Brazil (2 trials), Taiwan (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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