Early cognitive changes after same-day hip or knee replacement
Official title: Early Cognitive Changes in Patients Aged 70 Years or Older After Same-day Discharge Hip and Knee Arthroplasty: A Prospective Cohort Study
Run by Odense University Hospital · NCT07598552 · Data updated 2026-11-12
This study tests whether older adults (65 or older, 70 per description) who have same-day discharge after hip or knee replacement show changes in cognitive test performance from before surgery to the first day after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 70 Years and up |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Odense University Hospital Academic / other |
| Locations | 1 site (Svendborg) |
| Status | Recruiting |
| Started | May 18, 2026 |
| Main results expected | October 31, 2026 |
| Study ends | November 30, 2026 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT07598552 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Candidates are native Danish speakers aged 70 or older undergoing unilateral primary total hip, total knee, or unicompartmental knee arthroplasty with spinal anesthesia and discharge on the day of surgery.
✕Probably not a fit
Patients who do not experience cognitive changes may not directly benefit beyond contributing to overall knowledge of POCD in this setting.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study follows participants aged 70 and older undergoing unilateral hip or knee arthroplasty with same-day discharge. Cognitive testing is performed virtually 14 days before surgery, then on postoperative day 1 and day 7. Pain levels and analgesic use are recorded during the first week after surgery to explore potential associations with cognitive changes. The study aims to describe early postoperative cognitive changes in the context of fast-track, ambulatory joint replacement and to contribute to understanding POCD in elderly patients undergoing streamlined perioperative care.
Why it matters
Potential benefit: Findings could help clinicians identify early cognitive changes after same-day joint replacement, informing monitoring and pain management strategies.
How similar studies have gone: Prior fast-track and ambulatory orthopedic protocols have reduced length of stay and some complications, but studies on early cognitive changes in this exact same-day, Danish-orthopedic population are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Unilateral elective primary Total Hip Arthroplasty, Total Knee Arthroplasty, or Unicompartmental Knee * Native Danish speaker * Spinal anesthesia Exclusion Criteria: * Inability or unwillingness to provide informed consent * Inability to comply with virtual study procedures or follow-up sessions, including because of visual or hearing impairment * Known dementia or other diagnosed cognitive disorders or Brief Assessment of Impaired Cognition (BASIC)≤20 * Parkinson's disease or other neurological conditions causing functional impairment * History of alcohol abuse (≥35 units per week) * Daily use of anxiolytics or hypnotics * Not discharged on the day of surgery
Where it's running
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Odense University Hospital, Svendborg Hospital
Svendborg, Denmark Recruiting
Study contacts
- Principal investigator: Martin Lindberg-Larsen, Professor — Head of Research / Consultant Orthopaedic Surgeon at Odense University Hospital. Department of Clinical Research, University of Southern Denmark (SDU)
- Study coordinator: Abdullahi Abdirisak Hirsi, MD
- Email: abdullahi.abdirisak.hirsi2@rsyd.dk
- Phone: +4553376575
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.