Understanding how calcium channels affect substance use and mood disorders
L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood Disorders
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11144027
This study is looking at how problems with drugs and mood can affect each other, especially when someone is trying to stay off drugs, and it’s testing how certain brain channels might help us find better treatments for people dealing with both issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11144027 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between substance use disorders and mood disorders, focusing on the role of L-type calcium channels in the brain. It aims to uncover the mechanisms that link these conditions, particularly during periods of drug abstinence when mood and anxiety symptoms can worsen. By using rodent models, the study examines how activating or blocking these calcium channels influences behaviors related to drug seeking, anxiety, and depression. The goal is to identify new therapeutic targets that could improve treatment options for individuals facing these comorbid conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals struggling with substance use disorders who also experience mood or anxiety disorders.
Not a fit: Patients who do not have comorbid substance use and mood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better address both substance use and mood disorders simultaneously.
How similar studies have performed: Previous research has shown promise in understanding the role of calcium channels in mood and substance use disorders, indicating that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ADDY, NII A — YALE UNIVERSITY
- Study coordinator: ADDY, NII A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders, Anxiety Disorders, Bipolar Disorder