Understanding how calcium channels affect substance use and mood disorders
Official title: L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood Disorders
Funded at Yale University · NIH-11144027 · Data updated 2026-11-12
This study is looking at how problems with drugs and mood can affect each other, especially when someone is trying to stay off drugs, and it’s testing how certain brain channels might help us find better treatments for people dealing with both issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $85,009 |
| NIH project number | 3R01DA050454-05S1 |
| Project ID | NIH-11144027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals struggling with substance use disorders who also experience mood or anxiety disorders.
✕Less likely to help
Patients who do not have comorbid substance use and mood disorders may not benefit from this research.
What this research studies
This research investigates the relationship between substance use disorders and mood disorders, focusing on the role of L-type calcium channels in the brain. It aims to uncover the mechanisms that link these conditions, particularly during periods of drug abstinence when mood and anxiety symptoms can worsen. By using rodent models, the study examines how activating or blocking these calcium channels influences behaviors related to drug seeking, anxiety, and depression. The goal is to identify new therapeutic targets that could improve treatment options for individuals facing these comorbid conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better address both substance use and mood disorders simultaneously.
How similar studies have gone: Previous research has shown promise in understanding the role of calcium channels in mood and substance use disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Addy, Nii a — Yale University
- Study coordinator: Addy, Nii a
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Understanding how calcium channels affect substance use and mood disorders
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.