Videoconference Brief Cognitive Behavioral Therapy for mood disorders at high suicide risk

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study has a cross-sectional baseline comparison followed by a randomized controlled trial to examine inflammatory biomarkers related to suicide risk and to test the effectiveness of videoconference-based brief cognitive-behavioral therapy (V-BCBT) in mood disorder patients. Participants include adults with depressive disorders or bipolar and related disorders, some at high suicide risk and others at low risk, plus healthy controls. All participants will undergo clinical interviews, self-report questionnaires, a Death Implicit Association Test, and blood sampling to profile inflammatory markers. The intervention arm receives V-BCBT, while the control arm receives treatment as usual, with outcomes including mood symptoms and suicidality, as well as biomarker correlations. The study aims to identify biomarkers linked to suicide risk and to assess whether V-BCBT can reduce risk indicators and improve clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 to 64 years.
* For patient groups: diagnosis of a depressive disorder or bipolar and related disorder with a current major depressive episode according to DSM-5 criteria, as assessed using the Mini International Neuropsychiatric Interview (MINI).
* For the high-suicide-risk group: either a suicide attempt within the past month or a Beck Scale for Suicide Ideation (SSI) score of ≥15.
* For healthy controls: no lifetime history of any DSM-5 psychiatric disorder, as assessed using the MINI.

Exclusion Criteria:

* Presence of psychotic symptoms or a current substance use disorder.
* Diagnosis of an inflammatory or autoimmune disease.
* Use of corticosteroids or immunosuppressive medications within the past month.
* Current pregnancy or breastfeeding.
* Diagnosis of cancer within the past 5 years.
* Physical injury or infectious illness within the past month.
* Night-shift work within the past 2 months.
* Receipt of psychotherapy or psychological treatment within the past 3 months.
* Use of anti-inflammatory medications within the past 2 weeks.

Where it's running

• Asan Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Christopher Hyung Keun Park, M.D., Ph.D.
• Email: hkpark@gmail.com
• Phone: +82-2-3010-1657

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.