Condition

Depressive Disorder, Treatment-Resistant clinical trials and research

• 11Clinical trials
• 1New in 30 days
• 7Countries

Newest Depressive Disorder, Treatment-Resistant clinical trials

All recruiting trials (11)

• SAINT therapy for memory issues in older adults with treatment-resistant depression

  This study tests whether SAINT®, a personalized, accelerated TMS treatment, can safely improve memory and mood in adults 65 and older with treatment-resistant depression and memory concerns.

  Recruiting BrainHealth Solutions, Inc. · Costa Mesa, California · NCT07876908

• One-Day cTBS Over the Precuneus and iTBS Over the Left PFC for Treatment-Resistant Depression

  This study tests whether a one-day accelerated TMS session targeting the precuneus or the left dorsolateral prefrontal cortex can reduce depressive symptoms in adults with treatment-resistant depression, compared with sham stimulation.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT07758010

• Esketamine nasal spray vs placebo for adults with treatment-resistant depression

  In adults who have not responded to at least two antidepressants, one of two doses of esketamine nasal spray is tested against placebo to see if it can help reduce depressive symptoms.

  Recruiting at 39 sites Phase 3 Janssen Research & Development, LLC · Redlands, California and 38 other locations · NCT07716098

• ACP-211 alone for adults whose depression hasn't improved with antidepressants

  This trial tests whether ACP-211 can help adults with major depressive disorder who haven't improved on antidepressants do better than a placebo.

  Recruiting at 24 sites Phase 2 ACADIA Pharmaceuticals Inc. · Birmingham, Alabama and 27 other locations · NCT07284667

• Accelerated versus once-daily theta-burst stimulation for late-life depression

  This test compares multiple theta-burst brain stimulation sessions per day to one session per day to see which better reduces symptoms in people 60 and older with moderate to severe treatment-resistant depression.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT06854367

• Using intravenous ketamine to treat severe depression that hasn't responded to other treatments

  This study is testing if intravenous ketamine can help adults with severe depression that hasn't improved with other treatments feel better.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT06668571

• Testing a new drug for treatment-resistant depression

  This study is testing a new drug called HNK to see if it can help people with treatment-resistant depression feel better when other medications haven't worked.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06511908

• OSU6162 for patients with depression not helped by standard treatments

  This study is testing if a new medication called OSU6162 can help people with depression who haven't found relief from standard treatments.

  Recruiting at 2 sites Phase 2 Göteborg University · Lund, Skåne County and 3 other locations · NCT05641623

• Using rTMS with and without supportive text messages to treat resistant depression

  This study is testing if adding supportive text messages to a brain treatment can help adults with tough-to-treat depression feel better compared to just the brain treatment alone.

  Recruiting at 2 sites University of Alberta · Edmonton, Alberta and 1 other locations · NCT05570344

• Comparing classic and deep rTMS treatments for depression

  This study is testing whether a new type of brain stimulation treatment for depression works better than a classic version for people who haven't found relief from other therapies.

  Recruiting Centre Hospitalier Henri Laborit · Poitiers · NCT04956016

• Nitrous oxide targets brain circuits involved in mood

  This research will test whether inhaled nitrous oxide changes brain connectivity and improves symptoms in adults with treatment-resistant major depression compared with healthy volunteers.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT02994433

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Quick answers

How many Depressive Disorder, Treatment-Resistant clinical trials are recruiting right now?

11, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (7 trials), Canada (2 trials), France (1 trial), China (1 trial), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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