A platform for collecting data on mood disorders
Official title: Enabling Neuroscience Research Approaches for Brain, feeLings and Emotions (ENABLE): An Innovative Platform for Clinical Trials in Mood Disorders
Run by St. Joseph's Healthcare Hamilton · NCT06408012 · Data updated 2026-11-12
This study is trying to create a better way to collect information from people with mood disorders like depression and bipolar disorder to help find new treatments that work for them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 2200 (estimated) |
| Sponsor | St. Joseph's Healthcare Hamilton Academic / other |
| Locations | 9 sites (Calgary, Alberta and 8 other locations) |
| Status | Recruiting |
| Started | October 17, 2023 |
| Main results expected | March 31, 2029 |
| Study ends | March 31, 2029 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT06408012 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 16 and older who meet the criteria for bipolar or depressive disorders as defined by DSM-5.
✕Probably not a fit
Patients without a history of psychiatric disorders or significant unstable medical conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The ENABLE platform aims to standardize data collection methods for individuals with mood disorders, including depression and bipolar disorder, to facilitate the identification of biomarkers. It provides a structured approach for deep clinical and neurobiological phenotyping, creating a recruitment pool for future clinical trials. Participants will complete clinical assessments and may provide biological samples and undergo neuroimaging procedures. This initiative seeks to enhance the understanding of mood disorders and improve treatment matching for affected individuals.
Why it matters
Potential benefit: If successful, this platform could lead to more personalized and effective treatments for mood disorders.
How similar studies have gone: Other studies have shown success in using standardized approaches to identify biomarkers in various conditions, suggesting potential for this novel platform.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria Patients: 1. 16 years of age or older. 2. Meet criteria for bipolar or depressive disorders as defined by DSM-5. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires. Inclusion Criteria Healthy Comparison (HC) Participants: 1. 16 years of age or older. 2. No history of psychiatric disorders (according to DSM-5) or significant unstable medical conditions. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.
Where it's running
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University of Calgary
Calgary, Alberta, Canada Recruiting -
University of British Columbia
Vancouver, British Columbia, Canada Recruiting -
Nova Scotia Health Authority
Halifax, Nova Scotia, Canada Recruiting -
McMaster University
Hamilton, Ontario, Canada Recruiting -
Queen's University
Kingston, Ontario, Canada Recruiting -
University of Ottawa
Ottawa, Ontario, Canada Recruiting
Show 3 more locations
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University Health Network
Toronto, Ontario, Canada Recruiting -
Centre for Addiction and Mental Health
Toronto, Ontario, Canada Recruiting -
Ontario Shores Centre for Mental Health Sciences
Whitby, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Benicio N Frey — St. Joseph's Healthcare Hamilton
- Study coordinator: Saba Khoshroo
- Email: skhoshro@stjoes.ca
- Phone: 905-522-1155
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.