A platform for collecting data on mood disorders
Enabling Neuroscience Research Approaches for Brain, feeLings and Emotions (ENABLE): An Innovative Platform for Clinical Trials in Mood Disorders
This study is trying to create a better way to collect information from people with mood disorders like depression and bipolar disorder to help find new treatments that work for them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 900 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | St. Joseph's Healthcare Hamilton Academic / other |
| Locations | 9 sites (Calgary, Alberta and 8 other locations) |
| Trial ID | NCT06408012 on ClinicalTrials.gov |
What this trial studies
The ENABLE platform aims to standardize data collection methods for individuals with mood disorders, including depression and bipolar disorder, to facilitate the identification of biomarkers. It provides a structured approach for deep clinical and neurobiological phenotyping, creating a recruitment pool for future clinical trials. Participants will complete clinical assessments and may provide biological samples and undergo neuroimaging procedures. This initiative seeks to enhance the understanding of mood disorders and improve treatment matching for affected individuals.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 16 and older who meet the criteria for bipolar or depressive disorders as defined by DSM-5.
Not a fit: Patients without a history of psychiatric disorders or significant unstable medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this platform could lead to more personalized and effective treatments for mood disorders.
How similar studies have performed: Other studies have shown success in using standardized approaches to identify biomarkers in various conditions, suggesting potential for this novel platform.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria Patients: 1. 16 years of age or older. 2. Meet criteria for bipolar or depressive disorders as defined by DSM-5. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires. Inclusion Criteria Healthy Comparison (HC) Participants: 1. 16 years of age or older. 2. No history of psychiatric disorders (according to DSM-5) or significant unstable medical conditions. 3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.
Where this trial is running
Calgary, Alberta and 8 other locations
- University of Calgary — Calgary, Alberta, Canada (Recruiting)
- University of British Columbia — Vancouver, British Columbia, Canada (Recruiting)
- Nova Scotia Health Authority — Halifax, Nova Scotia, Canada (Recruiting)
- McMaster University — Hamilton, Ontario, Canada (Recruiting)
- Queen's University — Kingston, Ontario, Canada (Recruiting)
- University of Ottawa — Ottawa, Ontario, Canada (Recruiting)
- University Health Network — Toronto, Ontario, Canada (Recruiting)
- Centre for Addiction and Mental Health — Toronto, Ontario, Canada (Recruiting)
- Ontario Shores Centre for Mental Health Sciences — Whitby, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Benicio N Frey — St. Joseph's Healthcare Hamilton
- Study coordinator: Saba Khoshroo
- Email: skhoshro@stjoes.ca
- Phone: 905-522-1155
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.