Clinical trial Recruiting at 9 sites Observational Ages 16 and up

A platform for collecting data on mood disorders

Official title: Enabling Neuroscience Research Approaches for Brain, feeLings and Emotions (ENABLE): An Innovative Platform for Clinical Trials in Mood Disorders

Run by St. Joseph's Healthcare Hamilton · NCT06408012 · Data updated 2026-11-12

This study is trying to create a better way to collect information from people with mood disorders like depression and bipolar disorder to help find new treatments that work for them.

Quick facts

Study typeObservational
Ages16 Years and up
SexAll
Enrollment2200 (estimated)
SponsorSt. Joseph's Healthcare Hamilton
Academic / other
Locations9 sites (Calgary, Alberta and 8 other locations)
StatusRecruiting
StartedOctober 17, 2023
Main results expectedMarch 31, 2029
Study endsMarch 31, 2029
Registry record updatedJuly 13, 2026
Trial IDNCT06408012 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals aged 16 and older who meet the criteria for bipolar or depressive disorders as defined by DSM-5.

Probably not a fit

Patients without a history of psychiatric disorders or significant unstable medical conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The ENABLE platform aims to standardize data collection methods for individuals with mood disorders, including depression and bipolar disorder, to facilitate the identification of biomarkers. It provides a structured approach for deep clinical and neurobiological phenotyping, creating a recruitment pool for future clinical trials. Participants will complete clinical assessments and may provide biological samples and undergo neuroimaging procedures. This initiative seeks to enhance the understanding of mood disorders and improve treatment matching for affected individuals.

Why it matters

Potential benefit: If successful, this platform could lead to more personalized and effective treatments for mood disorders.

How similar studies have gone: Other studies have shown success in using standardized approaches to identify biomarkers in various conditions, suggesting potential for this novel platform.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria

Patients:

1. 16 years of age or older.
2. Meet criteria for bipolar or depressive disorders as defined by DSM-5.
3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.

Inclusion Criteria

Healthy Comparison (HC) Participants:

1. 16 years of age or older.
2. No history of psychiatric disorders (according to DSM-5) or significant unstable medical conditions.
3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.

Where it's running

  • University of Calgary
    Calgary, Alberta, Canada
    Recruiting
  • University of British Columbia
    Vancouver, British Columbia, Canada
    Recruiting
  • Nova Scotia Health Authority
    Halifax, Nova Scotia, Canada
    Recruiting
  • McMaster University
    Hamilton, Ontario, Canada
    Recruiting
  • Queen's University
    Kingston, Ontario, Canada
    Recruiting
  • University of Ottawa
    Ottawa, Ontario, Canada
    Recruiting
Show 3 more locations
  • University Health Network
    Toronto, Ontario, Canada
    Recruiting
  • Centre for Addiction and Mental Health
    Toronto, Ontario, Canada
    Recruiting
  • Ontario Shores Centre for Mental Health Sciences
    Whitby, Ontario, Canada
    Recruiting

Study contacts

  • Principal investigator: Benicio N Frey — St. Joseph's Healthcare Hamilton
  • Study coordinator: Saba Khoshroo
  • Email: skhoshro@stjoes.ca
  • Phone: 905-522-1155

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.