Understanding how reward processing differs in genetic frontotemporal dementia and mood disorders
Official title: Reward processing in genetic frontotemporal dementia and mood disorders
Funded at University of California, San Francisco · NIH-10543554 · Data updated 2026-11-12
This study is looking at how people with genetic frontotemporal dementia and mood disorders experience rewards differently, so we can better understand these conditions and help improve how they are diagnosed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | March 1, 2019 |
| Project end | December 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $767,651 |
| NIH project number | 5R01AG059794-05 |
| Project ID | NIH-10543554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic mutations associated with frontotemporal dementia, as well as those diagnosed with major depressive disorder or bipolar disorder.
✕Less likely to help
Patients without genetic predispositions to frontotemporal dementia or those who do not have mood disorders may not benefit from this research.
What this research studies
This research investigates the differences in how individuals with genetic frontotemporal dementia (FTD) and mood disorders process rewards. By examining the earliest behavioral changes in patients with genetic mutations linked to FTD, the study aims to identify distinguishing features between FTD and psychiatric conditions like major depressive disorder and bipolar disorder. The research will involve comparing reward processing in various groups, including presymptomatic genetic FTD patients, their family members, and individuals with mood disorders, to better understand these conditions and improve diagnostic accuracy.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatments for patients with frontotemporal dementia and mood disorders.
How similar studies have gone: Previous research has shown promise in understanding the overlap between neurodegenerative diseases and psychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Perry, David C — University of California, San Francisco
- Study coordinator: Perry, David C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.