Comparing Lemborexant, Zopiclone, and Clonidine for treating insomnia in chronic pain patients
Official title: Lemborexant vs Clonidine vs Zopiclone vs Other Sedatives for Managing Chronic Insomnia in Chronic Pain Patients
Run by Salem Anaesthesia Pain Clinic · NCT05618002 · Data updated 2026-11-12
This study is testing whether Lemborexant, Zopiclone, or Clonidine can help people with chronic pain sleep better and manage their pain.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 99 Years |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Salem Anaesthesia Pain Clinic Academic / other |
| Locations | 1 site (Surrey, British Columbia) |
| Status | Recruiting |
| Started | January 2, 2023 |
| Main results expected | June 28, 2027 |
| Study ends | June 28, 2027 |
| Registry record updated | November 2, 2026 |
| Trial ID | NCT05618002 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with chronic pain and severe insomnia who have not responded to non-pharmacologic sleep therapies.
✕Probably not a fit
Patients with conditions such as obstructive sleep apnea, cognitive disorders, or those on high doses of opioids may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational crossover study involves 150 adult patients with chronic pain who also suffer from insomnia. Participants will alternate between taking prescribed doses of Lemborexant, Zopiclone, or Clonidine on different nights over a three-week period. They will maintain a validated sleep diary to track their pain and sleep scores, medication usage, and any adverse effects. The study aims to evaluate the safety and efficacy of these medications in improving sleep quality and managing pain.
Why it matters
Potential benefit: If successful, this study could provide insights into more effective insomnia treatments for patients suffering from chronic pain.
How similar studies have gone: While there have been studies on insomnia treatments, this specific comparison of Lemborexant, Zopiclone, and Clonidine in chronic pain patients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult chronic pain patients * good treatment compliance * severe chronic insomnia * failure of non-pharmacologic sleep therapy * regular night sedative therapy for 3 months or more * regular sleep diary * regular pain and mood diary * informed consent for diary review * consent for clinical record quality assurance review Exclusion Criteria: * obstructive sleep apnoea * body mass index (BMI) ≥40 * organ insufficiency * cognitive disorder * inability to provide consent * major neuropsychiatric disorder * unreliable diary * cannabis use * regular alcohol intake * stimulant use * substance abuse * poor treatment compliance * high dose opioid * gabapentinoid use * other sedative use * mild insomina * irregular sedative intake * regular sedative therapy for less than 3 months * previous adverse/allergic reactions to clonidine or zopiclone
Where it's running
-
Salem Anaesthesia Pain Clinic
Surrey, British Columbia, Canada Recruiting
Study contacts
- Principal investigator: Olu Bamgbade, MD, CPI, FRCPC, PMP, DBA — Salem Anaesthesia Pain Clinic
- Study coordinator: Olu Bamgbade, MD, CPI, FRCPC, PMP, DBA
- Email: salem.painclinic@gmail.com
- Phone: +17786286600
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.