Youth suicide risk factors and personalized reduction strategies in young adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

YOU-SURF aims to integrate multimodal data to identify risk factors for suicide in youth and test a dTMS-based intervention. The study includes clinical assessments, blood tests, genome-wide genotyping, and neuroimaging, alongside an innovative neuromodulation treatment. It compares participants with mood disorders aged 18–25 to a control group without DSM-5 disorders, all undergoing MRI and Italian-language screening. The approach targets personalized risk profiling and tailored treatment strategies based on multiple biological and clinical dimensions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of mood disorder (major depressive episode, major depressive disorder, or bipolar disorder) according to DSM-5;
* Age between 18 and 25 years;
* Eligibility for magnetic resonance imaging;
* Proficiency in the Italian language.

Exclusion Criteria:

* Comorbidity with severe neurological or medical conditions;
* Diagnosis of cognitive impairment;
* Inability to provide informed consent.

For the control group:

Inclusion Criteria:

the same as the experimental group.

Exclusion Criteria:

* subjects with DSM-5 disorders
* subjects with a family history of psychiatric disorders will be excluded.

Where it's running

• Fondazione Policlinico Universitario A. Gemelli IRCCS - UOC Psichiatria Clinica e d'Urgenza
  Roma, Rm, Italy Recruiting

Study contacts

• Principal investigator: Delfina Janiri — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Delfina Janiri
• Email: delfina.janiri@unicatt.it
• Phone: +390630159527

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.