Understanding how calcium channels affect substance use and mood disorders
Official title: L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood Disorders
Funded at Yale University · NIH-10887588 · Data updated 2026-11-12
This study is looking at how problems with drugs and mood, like anxiety and depression, are connected in the brain, especially when someone is trying to stay off drugs, and it hopes to find new ways to help people who struggle with both issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $377,091 |
| NIH project number | 5R01DA050454-05 |
| Project ID | NIH-10887588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals struggling with substance use disorders who also experience mood or anxiety disorders.
✕Less likely to help
Patients who do not have substance use disorders or mood disorders may not benefit from this research.
What this research studies
This research investigates the relationship between substance use disorders and mood disorders, focusing on the role of L-type calcium channels in the brain. It aims to uncover the mechanisms that link these conditions, particularly during periods of drug abstinence when symptoms may worsen. By using rodent models, the study examines how activating or blocking these calcium channels influences behaviors related to drug seeking, anxiety, and depression. The goal is to identify new therapeutic targets that could improve treatment outcomes for individuals facing both substance use and mood disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better address the challenges faced by patients with both substance use and mood disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of calcium channels in neuropsychiatric disorders, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Addy, Nii a — Yale University
- Study coordinator: Addy, Nii a
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Understanding how calcium channels affect substance use and mood disorders
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.