NIH-funded research NIH-funded research

Using a mobile app to enhance therapy for teens at risk of severe mood disorders

Official title: App-Enhanced CBT for Adolescents at High Risk for Severe Mood Disorders

Funded at University of California Los Angeles · NIH-10817156 · Data updated 2026-11-12

This study is looking to make therapy better for teens aged 12 to 20 who are at risk for serious mood issues, like depression and bipolar disorder, by using a helpful mobile app that reminds them to practice what they learn in therapy and track how they’re feeling.

More Mood research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of California Los Angeles
NIH-funded
Lab location1 site (Los Angeles, United States)
Project startApril 1, 2021
Project endMarch 31, 2026
Funding year2024
Award (this year)$194,832
NIH project number5K23MH124015-04
Project IDNIH-10817156 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adolescents aged 12 to 20 who are identified as being at high risk for severe mood disorders.

Less likely to help

Patients who are not at risk for severe mood disorders or who do not fall within the 12 to 20 age range may not benefit from this research.

What this research studies

This research focuses on improving cognitive-behavioral therapy (CBT) for adolescents aged 12 to 20 who are at high risk for severe mood disorders, such as bipolar disorder and major depression. The study aims to adapt a mobile health application that helps reinforce therapy content, encourages practice of treatment skills, and allows participants to track their thoughts and symptoms. By addressing common barriers like low motivation and forgetfulness, the research seeks to enhance patient engagement and adherence to treatment tasks, ultimately improving therapeutic outcomes.

Why it matters

Potential benefit: If successful, this research could lead to more effective treatment for adolescents at risk of severe mood disorders, potentially reducing their symptoms and improving their quality of life.

How similar studies have gone: Other research has shown promise in using mobile health technologies to enhance therapeutic engagement, suggesting that this approach could be effective.

Where this research is happening

  • University of California Los Angeles
    Los Angeles, United States
    Active

Researchers

  • Principal investigator: Weintraub, Marc Joshua — University of California Los Angeles
  • Study coordinator: Weintraub, Marc Joshua

Related research

Other NIH-funded projects on the same topics.

  • Understanding gene activity in the brains of people with mood disorders who died by suicide

    A study to map which genes are active in brain cells and where they are in the brains of people with mood disorders who attempted or died by suicide, using advanced single-cell and spatial techniques.

    NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11349216

  • Synaptic changes in mood disorders and suicide risk

    This project studies brain Synapse signals in people with mood disorders, including those with a recent suicide attempt, to understand what changes are linked to suicide risk and how ketamine might work.

    NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11349215

  • Integrating immune and brain reward biology in veterans with mood problems

    A study in veterans with mood disorders looks at how the immune system and brain reward circuits may work together to drive depression and suicide risk.

    NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11320777

  • Mindfulness to reduce mood swings in teens at risk for mood disorders

    This project teaches mindfulness skills to teens and young adults with family histories of mood disorders to help reduce frequent mood swings and improve sustained attention.

    NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11285153

  • Understanding how calcium channels affect substance use and mood disorders

    This study is looking at how problems with drugs and mood can affect each other, especially when someone is trying to stay off drugs, and it’s testing how certain brain channels might help us find better treatments for people dealing with both issues.

    NIH research Yale University · New Haven, United States · NIH-11144027

  • Exploring the link between immune system issues and mood disorders in veterans

    This study is looking at how problems with the immune system might affect mood and increase the risk of suicide in veterans, using blood tests and brain scans to find clues that could help improve diagnosis and treatment for those dealing with depression.

    NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11052103

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.