Identifying brain markers for mood disorders in at-risk youth
Official title: Neurobiological markers of risk and resilience for psychopathology in youth at familial risk for mood disorders
Funded at Yale University · NIH-11007275 · Data updated 2026-11-12
This study is looking at how the brains of young people with a family history of mood disorders, like depression and bipolar disorder, are different, so we can find signs that might help us predict who could develop these conditions in the future and help them get the right support early on.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $33,984 |
| NIH project number | 5F31MH131246-03 |
| Project ID | NIH-11007275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are youth aged 0-20 years with a family history of mood disorders.
✕Less likely to help
Patients without a family history of mood disorders or those already diagnosed with MDD or BD may not benefit from this research.
What this research studies
This research investigates the neurobiological differences in youth who have a family history of mood disorders, specifically major depressive disorder (MDD) and bipolar disorder (BD). By examining brain activity and structure, the study aims to identify biomarkers that can predict the onset of these disorders before symptoms appear. The approach includes longitudinal assessments to track changes over time, which may help distinguish between youth at high risk for BD versus MDD. This could lead to more effective early interventions and treatments for those at risk.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of mood disorders in youth, improving treatment outcomes.
How similar studies have gone: Previous studies have shown promise in identifying neurobiological markers for mood disorders, but this research aims to build on those findings with a larger sample size and more comprehensive methodologies.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Holt-Gosselin, Bailey — Yale University
- Study coordinator: Holt-Gosselin, Bailey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.