Condition

Lynch Syndrome clinical trials and research

• 29Clinical trials
• 18NIH research projects
• 13Countries

Newest Lynch Syndrome clinical trials

All recruiting trials (29)

• Capsule camera screening of the small intestine for people with Lynch syndrome

  This project looks back at past small-bowel capsule endoscopy exams to see if they detect precancerous lesions or early cancer in people with Lynch syndrome.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07472686

• Liquid biopsy and machine learning to detect early colorectal cancer, advanced adenomas, Lynch-related cancers, and residual disease

  This project will test a blood-based liquid biopsy that uses microRNA signals and machine learning to detect colorectal cancer, advanced adenomas, Lynch-associated cancers, and molecular residual disease in people who have a colonoscopy.

  Recruiting San Raffaele University · Milan, Lombardy and 3 other locations · NCT07450612

• Cutting down ultra-processed foods for people at high cancer risk

  This project tests whether using the Open Food Facts smartphone app alongside nutrition education helps adults at high risk of cancer eat fewer ultra-processed foods.

  Recruiting at 2 sites Gustave Roussy, Cancer Campus, Grand Paris · Avignon and 2 other locations · NCT07436312

• Menstrual cup for early detection of endometrial cancer in Lynch syndrome

  This project will test whether using a menstrual cup can collect uterine lining samples that help detect early endometrial cancer in menstruating people who carry Lynch syndrome gene changes.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07220239

• Lower GI imaging with a tethered camera capsule

  This test tries a small camera capsule on a string that takes pictures of the lower gut without sedation for adults who are healthy or who have Lynch syndrome, Crohn's disease, or other inflammatory bowel diseases.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07219537

• See how common Muir-Torre syndrome is among people with Lynch syndrome

  This study tests how common Muir-Torre syndrome is in people with a confirmed Lynch syndrome.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes, Gard · NCT07201012

• Vaginal self-swabs and a health questionnaire to check uterine cancer risk in people with Lynch syndrome

  This study tests whether people with Lynch syndrome who still have their uterus can use at-home vaginal swabs and a short health questionnaire to help spot early signs of uterine cancer.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07194551

• Personalized dendritic-cell vaccine using frameshift neoantigens to prevent cancer in Lynch syndrome carriers

  This trial will test a personalized vaccine made from your own blood cells to see if it is safe and sparks immune responses that might prevent cancer in people with Lynch syndrome.

  Recruiting Phase 1 Fundacion Clinic per a la Recerca Biomédica · Barcelona, Barcelona · NCT07163403

• Initial testing of an educational approach to genetic services for families at risk of Lynch syndrome

  This pilot study tests whether an information letter alone or with a booklet helps at-risk relatives decide about pursuing genetic services for Lynch syndrome.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07106359

• Using video capsules to examine patients with Lynch Syndrome

  This study is testing whether video capsules can be a good alternative to regular colonoscopies for people with Lynch Syndrome to help improve cancer screening.

  Recruiting Royal Marsden NHS Foundation Trust · London, (Select) · NCT06712095

• Understanding the immune response in Lynch syndrome patients

  This study is trying to see if certain antibodies in the immune system can help spot early signs of cancer in people with Lynch syndrome.

  Recruiting at 5 sites San Raffaele University · Monrovia, California and 4 other locations · NCT06708429

• Improving care for individuals with Lynch syndrome

  This study is trying to improve care for people with Lynch syndrome by collecting health information and samples to better understand the condition and support new ways to prevent and detect cancer.

  Recruiting University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT06582914

• Understanding genetic causes of neuroendocrine tumors in Mexican patients

  This study is trying to find out the genetic changes that cause neuroendocrine tumors in Mexican patients to help develop better treatments.

  Recruiting at 3 sites Universidad Nacional Autonoma de Mexico · Mexico City, Mexico City and 2 other locations · NCT06523582

• Screening for bladder cancer in people with Lynch syndrome using urine tests

  This study is testing a new urine test to see if it can better find bladder cancer early in people with Lynch syndrome compared to the usual methods.

  Recruiting at 2 sites Tampere University Hospital · Vancouver and 1 other locations · NCT06218433

• Using CAD-EYE for detecting cancer lesions in Lynch syndrome patients

  This study tests if using the CAD-EYE system during colonoscopies can help find cancer lesions better in people with Lynch syndrome compared to regular methods.

  Recruiting French Society of Digestive Endoscopy · Paris · NCT05963191

• Using videocapsule endoscopy to detect small bowel cancer in Lynch syndrome patients

  This study is testing whether a tiny camera capsule can help find small bowel cancer in people with Lynch syndrome.

  Recruiting San Raffaele University · Milan, Lombardy · NCT05704010

• Assessing Lynch Syndrome Frequency in Colorectal Cancer Patients

  This study is trying to find out how common Lynch syndrome is in people with colorectal cancer in Russia by looking at their blood and tumor samples over five years.

  Recruiting State Scientific Centre of Coloproctology, Russian Federation · Moscow · NCT05495776

• Effects of naproxen or aspirin on immune cells in Lynch syndrome patients

  This study is testing whether naproxen or aspirin can change immune cells and help with symptoms in people with Lynch syndrome.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05411718

• Collecting blood and stool samples to detect colorectal cancer in Lynch syndrome patients

  This study is testing a new stool DNA test to see if it can help find colorectal cancer in people with Lynch syndrome by collecting their blood and stool samples.

  Recruiting at 7 sites Mayo Clinic · Scottsdale, Arizona and 8 other locations · NCT05410977

• Evaluating genetic risk and screening for prostate cancer

  This study is testing if prostate MRIs can help men at high genetic risk for prostate cancer find aggressive forms of the disease earlier.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05129605

• Using mesalamine to prevent colorectal cancer in Lynch Syndrome patients

  This study is testing if taking mesalamine can help prevent colorectal cancer in people with Lynch Syndrome.

  Recruiting at 5 sites Phase 2 Karolinska University Hospital · Aalborg and 7 other locations · NCT04920149

• Identifying and caring for individuals with inherited cancer syndromes

  This study is testing whether free genetic testing can help find and support people with inherited cancer syndromes better than current methods.

  Recruiting at 2 sites OHSU Knight Cancer Institute · Portland, Oregon and 1 other locations · NCT04494945

• Registry for people at risk of pancreatic cancer

  This study is collecting information from people at risk of pancreatic cancer due to family history or genetic factors to see if regular check-ups can help catch the disease early.

  Recruiting at 4 sites Associazione Italiana per lo Studio del Pancreas · Rozzano, Milan and 3 other locations · NCT04095195

• Developing a liquid biopsy protocol for cancer research at Princess Margaret

  This study is trying to create a simple way to collect blood samples from cancer patients to see if analyzing certain molecules in their blood can help doctors understand their cancer better and track how it changes over time.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03702309

• Investigating factors influencing cancer risk in people with Lynch syndrome

  This study is trying to find out how lifestyle, diet, and genetics affect cancer risk in people with Lynch syndrome.

  Recruiting Wageningen University · Wageningen · NCT03303833

• Genetic testing for hereditary cancer in Switzerland

  This study is trying to see if testing family members of people with hereditary breast, ovarian cancer, or Lynch syndrome can help identify those at risk and improve their chances of early detection and management.

  Recruiting at 5 sites University of Basel · Fribourg, Canton of Fribourg and 8 other locations · NCT03124212

• Investigating genetic factors in childhood cancer

  This study is trying to find out if certain genes passed down in families can increase the risk of childhood cancer by looking at samples from kids who have had cancer and their relatives.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT03050268

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Screening for pancreatic cancer in high-risk individuals

  This study is testing different ways to check for early signs of pancreatic cancer in people who are at high risk due to genetic factors.

  Recruiting at 9 sites Phase 3 Johns Hopkins University · New Haven, Connecticut and 8 other locations · NCT02000089

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immune clues to prevent cancer in Lynch Syndrome

  A study exploring how immune signals and shared neoantigens in Lynch Syndrome could help prevent cancer by training the immune system to recognize and fight premalignant lesions.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11457459

• Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer

  This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.

  NIH research University of Chicago · Chicago, United States · NIH-11415083

• Behavioral tool to boost pre-test genetic counseling for Lynch syndrome families

  A risk-based program helps families at risk for Lynch syndrome get pre-test counseling more often, so they can learn about genetic testing and cancer prevention.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11393139

• Cancer vaccines for Lynch syndrome in a non-human primate model

  A researcher is testing a vaccine approach to help prevent Lynch syndrome–related cancers by training the immune system to recognize cancer-causing changes in the colon using a primate model.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11378426

• Neoantigen vaccine for Lynch syndrome immune interception

  A study to test a vaccine that teaches the immune system to recognize cancer-causing mutations in people with Lynch syndrome.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11223985

• Personalized colorectal cancer screening for people with Lynch syndrome

  This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11212167

• Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome

  This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.

  NIH research University of Chicago · Chicago, United States · NIH-11184230

• Helping family members at risk for Lynch syndrome get pre-test genetic counseling

  A new program to help relatives of people with Lynch syndrome get pre-test genetic counseling so they can learn about their cancer risk and next steps.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11182738

• Immune-based prevention for colorectal cancer in Lynch syndrome

  This project aims to harness immune-targeting approaches and a common anti-inflammatory pill to help prevent colorectal cancer in people with Lynch syndrome.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11176214

• Personalized colonoscopy schedule for people with Lynch syndrome

  This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11167473

• Increasing genetic counseling for families at risk of Lynch syndrome

  This study is all about helping families who might be at risk for Lynch syndrome get the genetic counseling they need, by figuring out what stops them from seeking help and creating helpful resources to encourage them to get tested for cancer sooner.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11138785

• A vaccine to prevent cancer in people with Lynch Syndrome

  This project is developing a vaccine to help prevent various cancers in people who have Lynch Syndrome.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11132877

• How immune factors influence cancer development in Lynch Syndrome

  This study is looking at how the immune system works in people with Lynch Syndrome, a genetic condition that raises the risk of cancer, to find better ways to prevent and treat cancer using new therapies.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11114039

• Improving colorectal cancer screening for people with Lynch syndrome

  This study is looking at how to improve cancer check-ups for people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer, so they can catch it early and have better outcomes, especially focusing on making sure everyone, including Black individuals who are diagnosed younger, gets the screen

  NIH research Columbia University Health Sciences · New York, United States · NIH-11047374

• Preventing colorectal cancer in patients with Lynch Syndrome using immune strategies

  This study is looking at how we can use the body's immune system to help prevent colorectal cancer in people with Lynch Syndrome by finding specific markers from genetic changes and testing a medication called naproxen to boost immune responses in the colon.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10923965

• Improving colorectal cancer screening for people with Lynch Syndrome

  This study is looking to improve colorectal cancer screening for people with Lynch Syndrome by creating personalized recommendations based on their unique genetic makeup, so they can get the right care without unnecessary procedures.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10894888

• Investigating a vaccine for preventing cancer in patients with Lynch Syndrome

  This study is testing a new vaccine designed to help prevent cancer in people with Lynch Syndrome, a genetic condition that raises the risk of colorectal cancer, using a special model to see how safe and effective it is.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10894856

• Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests

  This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.

  NIH research University of Chicago · Chicago, United States · NIH-10793009

Related topics

Quick answers

How many Lynch Syndrome clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (12 trials), Italy (4 trials), France (4 trials), Canada (3 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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