Condition

BRCA2 Mutation clinical trials and research

• 13Clinical trials
• 5Countries

Newest BRCA2 Mutation clinical trials

All recruiting trials (13)

• Platform for women with BRCA1 or BRCA2 mutations in Italy

  This project will try to collect clinical and follow-up data from women in Italy who carry pathogenic BRCA1 or BRCA2 mutations to build a national registry that can guide prevention and care.

  Recruiting at 4 sites Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Avellino and 39 other locations · NCT07253051

• Hormone replacement after risk-reducing salpingo-oophorectomy

  This trial will test whether adding a short educational video to usual counseling helps premenopausal people with BRCA1 or BRCA2 mutations who are planning risk-reducing salpingo-oophorectomy decide about hormone replacement therapy.

  Recruiting at 2 sites Duke University · Chapel Hill, North Carolina and 1 other locations · NCT06972719

• Adapted group cognitive-behavioral therapy for fear of cancer returning in women with BRCA1 or BRCA2 mutations

  This project tests an adapted group cognitive-behavioral therapy to reduce fear of cancer returning in women who carry BRCA1 or BRCA2 mutations and have finished primary treatment.

  Recruiting CHU de Quebec-Universite Laval · Québec, Quebec · NCT06817694

• Testing axatilimab with olaparib for advanced HER2-negative breast cancer with specific gene mutations

  This study is testing a new drug called axatilimab combined with olaparib to see if it helps people with advanced HER2-negative breast cancer who have specific gene mutations.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06488378

• Testing a new drug ETX-19477 for advanced solid tumors

  This study is testing a new drug called ETX-19477 to see if it can help people with advanced solid tumors that haven't responded to other treatments.

  Recruiting at 14 sites Phase 1/2 858 Therapeutics, Inc. · Phoenix, Arizona and 13 other locations · NCT06395519

• Combining Elacestrant with Olaparib for Advanced Breast Cancer Treatment

  This study is testing if adding elacestrant to olaparib can help people with advanced breast cancer who have specific genetic mutations live longer without their cancer getting worse.

  Recruiting at 35 sites Phase 2 GBG Forschungs GmbH · Stuttgart, Baden-Wurttemberg and 35 other locations · NCT06201234

• Combining niraparib and irinotecan for cancers with DNA repair gene mutations

  This study is testing a new combination of two cancer drugs, niraparib and irinotecan, to see if it's safe and effective for people with certain types of cancer that have DNA repair gene mutations.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT05694715

• New treatment approach for BRCA1/2 mutated triple negative breast cancer

  This study is testing a new treatment combining Olaparib and Pembrolizumab for people with BRCA1/2 mutated triple negative breast cancer to see if it works better after chemotherapy.

  Recruiting at 3 sites Phase 2 Okayama University · Gifu, Gifu and 2 other locations · NCT05485766

• Increasing Genetic Testing for Families at Risk of Cancer

  This study is testing a new way to encourage families at risk of cancer to get genetic testing by having healthcare providers reach out directly to them instead of relying on patients to share their results.

  Recruiting at 8 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT05420064

• Evaluating genetic risk and screening for prostate cancer

  This study is testing if prostate MRIs can help men at high genetic risk for prostate cancer find aggressive forms of the disease earlier.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05129605

• Treatment for metastatic cancer with BRCA or PALB2 mutations using chemotherapy and stem cells

  This study is testing a new treatment combining chemotherapy and stem cells for people with metastatic pancreatic or breast cancer who have BRCA or PALB2 mutations to see if it is safe and effective.

  Recruiting Phase 1 General Oncology, Inc. · Boston, Massachusetts and 1 other locations · NCT04150042

• Registry for people at risk of pancreatic cancer

  This study is collecting information from people at risk of pancreatic cancer due to family history or genetic factors to see if regular check-ups can help catch the disease early.

  Recruiting at 4 sites Associazione Italiana per lo Studio del Pancreas · Rozzano, Milan and 3 other locations · NCT04095195

• Developing a liquid biopsy protocol for cancer research at Princess Margaret

  This study is trying to create a simple way to collect blood samples from cancer patients to see if analyzing certain molecules in their blood can help doctors understand their cancer better and track how it changes over time.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03702309

Related topics

Quick answers

How many BRCA2 Mutation clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (7 trials), Canada (2 trials), Italy (2 trials), Germany (1 trial), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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