Screening for pancreatic cancer in high-risk individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to screen individuals at high risk for pancreatic cancer, including those with hereditary conditions such as Peutz-Jeghers Syndrome and specific gene mutations. Participants will undergo interventions including secretin administration, MRI scans, and tumor marker gene tests to identify early signs of cancer. The study is monitored by a quality assurance group to ensure safety and compliance with protocols. The goal is to improve early detection and outcomes for those predisposed to pancreatic cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hereditary Pancreatitis or
* Peutz-Jeghers Syndrome or
* Strong family history of pancreas cancer on one side of the family tree or
* Confirmed germline mutation carrier (BRCA2, FAMMM (CDKN2A/p16), PALB2, BRCA1, ATM, HNPCC, Lynch Syndrome (hMLH1, hMSH2, PMS2, hMSH6, EpCAM) PRSS1, PRSS2, R122H, N291l, SPINK1, CFTR
* Endoscopic evaluation of pancreas scheduled

Exclusion Criteria:

* Medical comorbidities or coagulopathy that contraindicate endoscopy
* Prior surgery that prevent optimal endoscopic ultrasound such as partial or complete gastrectomy with Bilroth or Roux-en-Y anastomosis
* Stricture or obstruction in the upper GI tract that does not allow passage of the echoendoscope
* Poor performance status
* Inability to provide informed consent
* Pregnancy.

Where it's running

• Yale University
  New Haven, Connecticut, United States Recruiting
• Johns Hopkins Hospital
  Baltimore, Maryland, United States Recruiting
• Dana Farber Cancer Center, Harvard University
  Boston, Massachusetts, United States Recruiting
• University of Michigan
  Ann Arbor, Michigan, United States Recruiting
• NYU Langone Medical Center
  New York, New York, United States Recruiting
• Columbia University Medical Center
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Michael Goggins, MD — Johns Hopkins University
• Study coordinator: Hilary Cosby, RN
• Email: hcosby1@jhmi.edu

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.