See how common Muir-Torre syndrome is among people with Lynch syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will enroll patients with genetically confirmed Lynch syndrome who are treated at CHU de Nîmes to determine how often Muir-Torre syndrome occurs. They will analyze skin and other tumors using immunohistochemistry and microsatellite instability testing to understand tumor patterns linked to the genetic syndrome. A biobank of skin and tumor samples will be created for retrospective and prospective analyses, including smears from skin lesions and healthy tissue. The study will also describe dermatological manifestations and monitor for new tumors as recommended by practice guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient with a germline alteration of one of the MMR (MisMatch Repair) pathway genes (MLH1, PMS2, MSH2, MSH6) proven by constitutional genetic analysis (genetically authenticated Lynch syndrome).
* Patient followed at Nîmes University Hospital.
* Patient having given free and informed consent.
* Person affiliated to or benefiting from a social security scheme.

Exclusion Criteria:

* Person under court protection, guardianship or curatorship.
* A person who is unable to give consent.
* Person for whom it is impossible to give informed information.

Where it's running

• CHU de Nîmes
  Nîmes, Gard, France Recruiting

Study contacts

• Principal investigator: Pierre STOEBNER, Prof. — Nîmes University Hospital
• Study coordinator: Eric FROUIN, Dr.
• Email: Eric.frouin@chu-nimes.fr
• Phone: +334 66 68 82 74

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Capsule camera screening of the small intestine for people with Lynch syndrome

  This project looks back at past small-bowel capsule endoscopy exams to see if they detect precancerous lesions or early cancer in people with Lynch syndrome.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07472686

• Liquid biopsy and machine learning to detect early colorectal cancer, advanced adenomas, Lynch-related cancers, and residual disease

  This project will test a blood-based liquid biopsy that uses microRNA signals and machine learning to detect colorectal cancer, advanced adenomas, Lynch-associated cancers, and molecular residual disease in people who have a colonoscopy.

  Recruiting San Raffaele University · Milan, Lombardy and 3 other locations · NCT07450612

• Cutting down ultra-processed foods for people at high cancer risk

  This project tests whether using the Open Food Facts smartphone app alongside nutrition education helps adults at high risk of cancer eat fewer ultra-processed foods.

  Recruiting at 2 sites Gustave Roussy, Cancer Campus, Grand Paris · Avignon and 2 other locations · NCT07436312

• Menstrual cup for early detection of endometrial cancer in Lynch syndrome

  This project will test whether using a menstrual cup can collect uterine lining samples that help detect early endometrial cancer in menstruating people who carry Lynch syndrome gene changes.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07220239

• Lower GI imaging with a tethered camera capsule

  This test tries a small camera capsule on a string that takes pictures of the lower gut without sedation for adults who are healthy or who have Lynch syndrome, Crohn's disease, or other inflammatory bowel diseases.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07219537

• Vaginal self-swabs and a health questionnaire to check uterine cancer risk in people with Lynch syndrome

  This study tests whether people with Lynch syndrome who still have their uterus can use at-home vaginal swabs and a short health questionnaire to help spot early signs of uterine cancer.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07194551

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.