Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests
FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10793009 on NIH RePORTER |
What this research studies
This research investigates how to enhance colorectal cancer surveillance for individuals with Lynch syndrome by integrating noninvasive tests, like the fecal immunochemical test (FIT), with traditional colonoscopy. The study will assess the effectiveness and patient acceptance of these noninvasive tests compared to the standard invasive procedures. By collecting data from multiple centers, the research aims to develop personalized surveillance strategies that could reduce the number of colonoscopies needed while maintaining effective cancer detection. Additionally, a biobank will be established to support future research on biomarkers and clinical outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lynch syndrome who are at increased risk for colorectal cancer.
Not a fit: Patients without Lynch syndrome or those who do not require colorectal cancer surveillance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to less invasive and more accessible colorectal cancer screening options for Lynch syndrome patients.
How similar studies have performed: Previous research has shown promise in using noninvasive tests for cancer screening, suggesting that this approach could be effective for Lynch syndrome patients as well.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kupfer, Sonia — University of Chicago
- Study coordinator: Kupfer, Sonia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.