Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests
Official title: FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
Funded at University of Chicago · NIH-10793009 · Data updated 2026-11-12
This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $701,911 |
| NIH project number | 1R01CA287257-01 |
| Project ID | NIH-10793009 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lynch syndrome who are at increased risk for colorectal cancer.
✕Less likely to help
Patients without Lynch syndrome or those who do not require colorectal cancer surveillance may not benefit from this research.
What this research studies
This research investigates how to enhance colorectal cancer surveillance for individuals with Lynch syndrome by integrating noninvasive tests, like the fecal immunochemical test (FIT), with traditional colonoscopy. The study will assess the effectiveness and patient acceptance of these noninvasive tests compared to the standard invasive procedures. By collecting data from multiple centers, the research aims to develop personalized surveillance strategies that could reduce the number of colonoscopies needed while maintaining effective cancer detection. Additionally, a biobank will be established to support future research on biomarkers and clinical outcomes.
Why it matters
Potential benefit: If successful, this research could lead to less invasive and more accessible colorectal cancer screening options for Lynch syndrome patients.
How similar studies have gone: Previous research has shown promise in using noninvasive tests for cancer screening, suggesting that this approach could be effective for Lynch syndrome patients as well.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kupfer, Sonia — University of Chicago
- Study coordinator: Kupfer, Sonia
Related research
Other NIH-funded projects on the same topics.
-
Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
-
Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
-
Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
-
Personalized colonoscopy schedule for people with Lynch syndrome
This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.
-
Improving colorectal cancer screening for people with Lynch syndrome
This study is looking at how to improve cancer check-ups for people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer, so they can catch it early and have better outcomes, especially focusing on making sure everyone, including Black individuals who are diagnosed younger, gets the screen
-
Improving colorectal cancer screening for people with Lynch Syndrome
This study is looking to improve colorectal cancer screening for people with Lynch Syndrome by creating personalized recommendations based on their unique genetic makeup, so they can get the right care without unnecessary procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.