Condition

Li-Fraumeni Syndrome clinical trials and research

• 10Clinical trials
• 5NIH research projects
• 5Countries

Newest Li-Fraumeni Syndrome clinical trials

All recruiting trials (10)

• Using video capsules to examine patients with Lynch Syndrome

  This study is testing whether video capsules can be a good alternative to regular colonoscopies for people with Lynch Syndrome to help improve cancer screening.

  Recruiting Royal Marsden NHS Foundation Trust · London, (Select) · NCT06712095

• Understanding genetic causes of neuroendocrine tumors in Mexican patients

  This study is trying to find out the genetic changes that cause neuroendocrine tumors in Mexican patients to help develop better treatments.

  Recruiting at 3 sites Universidad Nacional Autonoma de Mexico · Mexico City, Mexico City and 2 other locations · NCT06523582

• Using arsenic trioxide with chemotherapy to treat pediatric cancer with p53 mutations

  This study is testing if adding arsenic trioxide to chemotherapy can help children with Li-Fraumeni syndrome and p53 mutations fight their cancer more safely.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06088030

• Evaluating willingness to participate in genetic counseling comparison

  This study is trying to see how willing people with Li-Fraumeni syndrome are to join a future trial comparing regular genetic counseling to personalized genetic counseling.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05126810

• Registry for Li Fraumeni and Li Fraumeni-Like Syndromes

  This study is creating a registry to gather information from people with Li-Fraumeni and Li-Fraumeni-Like Syndromes to help understand these conditions better and improve diagnosis and research.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Emilia-Romagna and 1 other locations · NCT04982744

• Understanding Li-Fraumeni Syndrome and TP53 Variants

  This study is trying to understand cancer risks in people with Li-Fraumeni Syndrome or TP53 gene changes to help improve prevention and treatment options.

  Recruiting at 3 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT04541654

• Biobank for patients with Li-Fraumeni Syndrome and TP53 mutations

  This study is collecting health information and samples from people with Li-Fraumeni Syndrome and TP53 mutations, as well as their family members, to see how their genes affect cancer risk and to find better ways to screen for and treat these cancers.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT04367246

• Investigating genetic factors in childhood cancer

  This study is trying to find out if certain genes passed down in families can increase the risk of childhood cancer by looking at samples from kids who have had cancer and their relatives.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT03050268

• Understanding Li-Fraumeni Syndrome and its Cancer Risks

  This study looks at people with Li-Fraumeni Syndrome to see what causes their cancer risk and how it affects their families, while also working on a cancer screening program.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT01443468

• Characterizing patients with rare cardiovascular diseases

  This study is trying to learn more about rare heart diseases by testing people who have these conditions, their family members, and healthy volunteers to see how these diseases develop and what causes them.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT01143454

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Refolding Mutant p53: A Strategy to Help People with Li-Fraumeni Syndrome

  Aims to develop drugs that stabilize mutant p53 in people with Li-Fraumeni syndrome to prevent cancers before they develop.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11415067

• Cancer screening with cell-free DNA in Li-Fraumeni Syndrome

  A new, patient-friendly screening approach using blood tests to look for cancer signals in people with Li-Fraumeni Syndrome, alongside standard imaging.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11291983

• Reversing mutations in a protein linked to cancer risk

  This study is exploring a new way to help people with certain genetic mutations that affect the VHL protein, which can increase cancer risk, by developing compounds that might help the protein work better and reduce the chances of cancer.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11174990

• Helping mutated p53 fold correctly to lower cancer risk in Li‑Fraumeni syndrome

  This project tests drugs that help mutated p53 protein fold properly to lower cancer risk for people with Li‑Fraumeni syndrome.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11168825

• Improving cancer prevention for people with Li-Fraumeni syndrome

  This study is looking at how to create new medications that can help people with Li-Fraumeni syndrome by fixing a faulty protein linked to cancer, with the goal of preventing tumors from developing.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10909964

Related topics

Quick answers

How many Li-Fraumeni Syndrome clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (6 trials), Italy (1 trial), United Kingdom (1 trial), China (1 trial), Mexico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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