Investigating factors influencing cancer risk in people with Lynch syndrome
The GEOLynch Cohort Study: Genetic, Environmental and Other Factors That Influence Tumour Risk Among Persons With Lynch Syndrome
Wageningen University · NCT03303833
This study is trying to find out how lifestyle, diet, and genetics affect cancer risk in people with Lynch syndrome.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Wageningen University (other) |
| Locations | 1 site (Wageningen) |
| Trial ID | NCT03303833 on ClinicalTrials.gov |
What this trial studies
The GEOLynch cohort study focuses on individuals with Lynch syndrome, a genetic condition that increases the risk of certain cancers. Participants are asked to complete questionnaires regarding their lifestyle, diet, and health, and provide biological samples for genetic analysis. The study aims to understand how genetic, environmental, and lifestyle factors contribute to tumor risk in this population. It has been ongoing since 2006, with both new and previous participants contributing data and samples for future research.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18 to 80 with a confirmed mutation in genes associated with Lynch syndrome.
Not a fit: Patients with additional hereditary cancer syndromes, chronic inflammatory bowel disease, or severe mental conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and prevention strategies for individuals with Lynch syndrome.
How similar studies have performed: Other studies have shown success in understanding cancer risks in hereditary syndromes, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Persons with a known mutation in a gene that causes Lynch syndrome, i.e. with an inherited monoallelic pathogenic germline mutation in either the MLH1, MSH2, MSH6, PMS2 or EPCAM gene. * Aged between 18 and 80 years at inclusion. Exclusion Criteria: * Additional carrier of another hereditary colon cancer predisposition syndrome (e.g. FAP) * (Chronic) Inflammatory bowel disease * Non-Dutch speaking * Dementia or another mental condition that makes it impossible to fill out questionnaires * Terminally ill persons
Where this trial is running
Wageningen
- Wageningen University — Wageningen, Netherlands (RECRUITING)
Study contacts
- Principal investigator: Ellen Kampman, PhD — Wageningen University
- Study coordinator: Fränzel van Duijnhoven, PhD
- Email: franzel.vanduijnhoven@wur.nl
- Phone: +31 317 485 375
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Lynch Syndrome, Neoplasms, Hereditary Nonpolyposis Colorectal Cancer, Colorectal Neoplasms, Lifestyle, Nutrition