Initial testing of an educational approach to genetic services for families at risk of Lynch syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a two-arm randomized pilot trial aimed at refining methods and materials for encouraging genetic counseling and testing among relatives of people with Lynch syndrome. Eligible participants are English-speaking adults who are blood relatives of a person diagnosed with Lynch syndrome and have not yet had genetic counseling or testing. Participants are randomized to receive either an information letter or an information letter plus a booklet, with surveys at baseline, 6 months, and an optional exit interview to collect feedback. The study will assess feasibility, recruitment, retention, and participants’ reactions to the education materials.

Why it matters

Who can join: the full rules

Probands Inclusion Criteria:

* English speaking
* at least 18 years old
* have had genetic testing for Lynch syndrome (LS)
* do not have a condition that would interfere with their ability to provide informed consent and complete study activities (e.g., cognitive dysfunction evaluated using clinical judgment during screening)

Clinical Trial Participants Inclusion Criteria:

* English-speaking
* at least 18 years old
* a blood relative of a patient who was diagnosed with LS
* potentially at risk for LS
* have not scheduled or had pre-test genetic counseling or genetic testing for LS
* do not have a personal history of a cancer (excluding non-melanoma skin cancer)
* do not have a condition that would interfere with their ability to provide informed consent and complete study activities (e.g., cognitive dysfunction evaluated using clinical judgment during screening)

Where it's running

• UAB
  Birmingham, Alabama, United States Recruiting

Study contacts

• Study coordinator: Haoyang Yan, PhD
• Email: LSPilotStudy@uabmc.edu
• Phone: 205-914-2249

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.