Assessing Lynch Syndrome Frequency in Colorectal Cancer Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational multicenter registry study aims to evaluate the frequency of Lynch syndrome among patients diagnosed with colorectal cancer in Russia. Blood and tumor samples will be collected from participants, with microsatellite instability assessed through various methods available at the participating centers. The study will follow patients for five years to correlate genetic mutations with clinical data, treatment effectiveness, and familial cancer patterns. The goal is to enhance understanding of Lynch syndrome's impact on treatment strategies in the Russian context.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provision of written informed consent;
* Patients with histologically verified colon adenocarcinoma or patients with histologically verified synchronous neoplasms who have not previously received treatment for a second tumor;
* Age ≥ 18 years;
* Absence of antitumor treatment for a real tumor (it is allowed to include patients who have a history of antitumor treatment for other malignant tumors, if the period after treatment is more than 12 months).
* The ability of the patient, according to the Researcher, to fulfill the requirements of the Protocol;

Exclusion Criteria:

\- Patients receiving chemotherapy or radiotherapy for colon cancer at the time of screening

Where it's running

• State Scientific Centre of Coloproctology
  Moscow, Russia Recruiting

Study contacts

• Principal investigator: Alexey Tsukanov, PhD — Head of the Department of Laboratory Genetics
• Study coordinator: Dmitrii Semenov, PhD
• Email: dr.semenov@inbox.ru
• Phone: +7 (985) 2632870

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  This project will test a blood-based liquid biopsy that uses microRNA signals and machine learning to detect colorectal cancer, advanced adenomas, Lynch-associated cancers, and molecular residual disease in people who have a colonoscopy.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.