Behavioral tool to boost pre-test genetic counseling for Lynch syndrome families
Official title: Development and Initial Testing of a Behavioral Intervention to Increase Pre-Test Genetic Counseling Among Families at Risk of Lynch Syndrome
Funded at University of Alabama at Birmingham · NIH-11393139 · Data updated 2026-11-12
A risk-based program helps families at risk for Lynch syndrome get pre-test counseling more often, so they can learn about genetic testing and cancer prevention.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00CA277584-05 |
| Project ID | NIH-11393139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Relatives of individuals diagnosed with Lynch syndrome who have not personally had cancer and have not yet undergone pre-test genetic counseling.
✕Less likely to help
Individuals without a family history of Lynch syndrome or those who have already completed pre-test counseling may see little or no benefit.
What this research studies
This project aims to identify why relatives who are at risk for Lynch syndrome do or do not receive pre-test counseling and then create a behavior-change program to raise counseling uptake. It will build on existing informational resources and use theory-based strategies to motivate action. The team will test the program with families who have a known relative with Lynch syndrome to see if pre-test counseling rates improve.
Why it matters
Potential benefit: If successful, more at-risk relatives may complete pre-test counseling, leading to earlier detection and better cancer prevention.
How similar studies have gone: Previous efforts show that tailored information can increase counseling uptake, but this study focuses on a theory-based intervention in at-risk relatives.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Yan, Haoyang — University of Alabama at Birmingham
- Study coordinator: Yan, Haoyang
Related research
Other NIH-funded projects on the same topics.
-
Immune clues to prevent cancer in Lynch Syndrome
A study exploring how immune signals and shared neoantigens in Lynch Syndrome could help prevent cancer by training the immune system to recognize and fight premalignant lesions.
-
Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
-
Cancer vaccines for Lynch syndrome in a non-human primate model
A researcher is testing a vaccine approach to help prevent Lynch syndrome–related cancers by training the immune system to recognize cancer-causing changes in the colon using a primate model.
-
Neoantigen vaccine for Lynch syndrome immune interception
A study to test a vaccine that teaches the immune system to recognize cancer-causing mutations in people with Lynch syndrome.
-
Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
-
Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.