Preventing colorectal cancer in patients with Lynch Syndrome using immune strategies
Official title: Cancer Immune-Interception for Lynch Syndrome
Funded at University of Tx Md Anderson Can Ctr · NIH-10923965 · Data updated 2026-11-12
This study is looking at how we can use the body's immune system to help prevent colorectal cancer in people with Lynch Syndrome by finding specific markers from genetic changes and testing a medication called naproxen to boost immune responses in the colon.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 21, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $639,370 |
| NIH project number | 5R01CA257375-04 |
| Project ID | NIH-10923965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lynch Syndrome who are at high risk for developing colorectal cancer.
✕Less likely to help
Patients without Lynch Syndrome or those who have already developed advanced colorectal cancer may not benefit from this research.
What this research studies
This research focuses on Lynch Syndrome, a hereditary condition that significantly increases the risk of colorectal cancer. It investigates how the immune system can be harnessed to prevent cancer in patients with this syndrome by identifying specific neoantigens that arise from genetic mutations. The study aims to enhance the immune response through the use of chemopreventive agents like naproxen, which may activate immune cells in the colorectal area. By analyzing genomic data from pre-cancerous lesions, the research seeks to develop targeted immune-interception strategies.
Why it matters
Potential benefit: If successful, this research could lead to new preventive treatments for colorectal cancer in individuals with Lynch Syndrome.
How similar studies have gone: Previous research has shown promise in using immune strategies for cancer prevention, particularly in genetically predisposed populations, indicating potential success for this approach.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Vilar Sanchez, Eduardo — University of Tx Md Anderson Can Ctr
- Study coordinator: Vilar Sanchez, Eduardo
Related research
Other NIH-funded projects on the same topics.
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Immune clues to prevent cancer in Lynch Syndrome
A study exploring how immune signals and shared neoantigens in Lynch Syndrome could help prevent cancer by training the immune system to recognize and fight premalignant lesions.
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Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
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Behavioral tool to boost pre-test genetic counseling for Lynch syndrome families
A risk-based program helps families at risk for Lynch syndrome get pre-test counseling more often, so they can learn about genetic testing and cancer prevention.
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Cancer vaccines for Lynch syndrome in a non-human primate model
A researcher is testing a vaccine approach to help prevent Lynch syndrome–related cancers by training the immune system to recognize cancer-causing changes in the colon using a primate model.
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Neoantigen vaccine for Lynch syndrome immune interception
A study to test a vaccine that teaches the immune system to recognize cancer-causing mutations in people with Lynch syndrome.
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Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.