Investigating a vaccine for preventing cancer in patients with Lynch Syndrome
Official title: Cancer Immune-Interception in a Spontaneous Non-Human Primate Model of Lynch Syndrome
Funded at University of Tx Md Anderson Can Ctr · NIH-10894856 · Data updated 2026-11-12
This study is testing a new vaccine designed to help prevent cancer in people with Lynch Syndrome, a genetic condition that raises the risk of colorectal cancer, using a special model to see how safe and effective it is.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 22, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $606,579 |
| NIH project number | 5R01CA260761-03 |
| Project ID | NIH-10894856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lynch Syndrome who are at high risk for developing colorectal cancer.
✕Less likely to help
Patients without Lynch Syndrome or those who do not have a genetic predisposition to colorectal cancer may not benefit from this research.
What this research studies
This research focuses on developing a vaccine aimed at preventing cancer in individuals with Lynch Syndrome, a hereditary condition that significantly increases the risk of colorectal cancer. The study utilizes a non-human primate model to evaluate the safety and effectiveness of the vaccine, which targets specific neoantigens generated by mutations in the DNA mismatch repair genes. By analyzing immune responses and the potential for cancer prevention, the research aims to translate findings into human applications. Patients with Lynch Syndrome may benefit from insights gained through this innovative approach.
Why it matters
Potential benefit: If successful, this research could lead to a preventive vaccine that significantly reduces cancer risk for patients with Lynch Syndrome.
How similar studies have gone: Previous research has shown promise in using vaccines targeting neoantigens for cancer prevention, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Vilar Sanchez, Eduardo — University of Tx Md Anderson Can Ctr
- Study coordinator: Vilar Sanchez, Eduardo
Related research
Other NIH-funded projects on the same topics.
-
Immune clues to prevent cancer in Lynch Syndrome
A study exploring how immune signals and shared neoantigens in Lynch Syndrome could help prevent cancer by training the immune system to recognize and fight premalignant lesions.
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Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
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Behavioral tool to boost pre-test genetic counseling for Lynch syndrome families
A risk-based program helps families at risk for Lynch syndrome get pre-test counseling more often, so they can learn about genetic testing and cancer prevention.
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Cancer vaccines for Lynch syndrome in a non-human primate model
A researcher is testing a vaccine approach to help prevent Lynch syndrome–related cancers by training the immune system to recognize cancer-causing changes in the colon using a primate model.
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Neoantigen vaccine for Lynch syndrome immune interception
A study to test a vaccine that teaches the immune system to recognize cancer-causing mutations in people with Lynch syndrome.
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Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.