Using CAD-EYE for detecting cancer lesions in Lynch syndrome patients
Official title: Evaluation of the CAD-EYE System for the Detection of Colorectal Neoplastic Lesions in Patients With Lynch Syndrome
Run by French Society of Digestive Endoscopy · NCT05963191 · Data updated 2026-11-12
This study tests if using the CAD-EYE system during colonoscopies can help find cancer lesions better in people with Lynch syndrome compared to regular methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 272 (estimated) |
| Sponsor | French Society of Digestive Endoscopy Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | April 18, 2024 |
| Main results expected | April 18, 2025 |
| Study ends | April 18, 2026 |
| Registry record updated | September 3, 2025 |
| Trial ID | NCT05963191 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals with confirmed pathogenic mutations associated with Lynch syndrome.
✕Probably not a fit
Patients who have undergone total colectomy or have a history of inflammatory bowel disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of the CAD-EYE system in enhancing the detection of neoplastic lesions during colorectal cancer screening in patients with Lynch syndrome. Lynch syndrome significantly increases the risk of colorectal cancer, making effective screening crucial. The study aims to compare the adenoma detection rate using CAD-EYE colonoscopy versus traditional methods. Participants will undergo colonoscopy with the CAD-EYE system to evaluate its potential benefits in improving cancer detection rates.
Why it matters
Potential benefit: If successful, this approach could lead to earlier and more accurate detection of colorectal cancer in patients with Lynch syndrome.
How similar studies have gone: While the use of artificial intelligence in colonoscopy is emerging, this specific application of CAD-EYE in Lynch syndrome patients is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed pathogenic mutation (path\_MLH1, path\_MSH2, path\_MSH6, path\_PMS2, path\_EpCAM) * Male or female of legal age at time of colonoscopy prescription. * Patient agreeing to participate in the study * Person affiliated with or benefiting from a social security scheme * Free, informed and express consent Exclusion Criteria: * Patient undergoing total colectomy with ileoanal or ileosigmoid anastomosis * Patient with a history of Crohn's disease or ulcerative colitis * Patients with a known allergy or intolerance to polyethylene glycol and ascorbic acid. * Patients unable to undergo fractionated colonic preparation * Inadequate colonic preparation: Boston sub-score \<2 per segment * Patient under guardianship or protected person * Patient who does not understand French or cannot read * Person not affiliated to a Social Security system. * Pregnant women
Where it's running
-
Hôpital Européen Georges-Pompidou HEGP
Paris, France Recruiting
Study contacts
- Study coordinator: Guillaume Perrod, MD
- Email: guillaume.perrod@aphp.fr
- Phone: +33 1 56 09 34 17
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Capsule camera screening of the small intestine for people with Lynch syndrome
This project looks back at past small-bowel capsule endoscopy exams to see if they detect precancerous lesions or early cancer in people with Lynch syndrome.
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Liquid biopsy and machine learning to detect early colorectal cancer, advanced adenomas, Lynch-related cancers, and residual disease
This project will test a blood-based liquid biopsy that uses microRNA signals and machine learning to detect colorectal cancer, advanced adenomas, Lynch-associated cancers, and molecular residual disease in people who have a colonoscopy.
-
Cutting down ultra-processed foods for people at high cancer risk
This project tests whether using the Open Food Facts smartphone app alongside nutrition education helps adults at high risk of cancer eat fewer ultra-processed foods.
-
Menstrual cup for early detection of endometrial cancer in Lynch syndrome
This project will test whether using a menstrual cup can collect uterine lining samples that help detect early endometrial cancer in menstruating people who carry Lynch syndrome gene changes.
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Lower GI imaging with a tethered camera capsule
This test tries a small camera capsule on a string that takes pictures of the lower gut without sedation for adults who are healthy or who have Lynch syndrome, Crohn's disease, or other inflammatory bowel diseases.
-
See how common Muir-Torre syndrome is among people with Lynch syndrome
This study tests how common Muir-Torre syndrome is in people with a confirmed Lynch syndrome.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.