Immune clues to prevent cancer in Lynch Syndrome

Who could benefit from this research

What this research studies

This project investigates how the body's immune system detects and responds to cancer-related changes in Lynch Syndrome, focusing on neoantigens created by mismatch repair defects. Researchers will look at how frameshift mutations generate shared targets across tumors and how T cells in blood reflect what happens inside tumors. The study also considers vaccination strategies and how early immune activation might stop premalignant polyps from turning into cancer. By combining immune profiling, biomarkers, and potential preventive approaches, the work aims to map paths to prevention in high-risk individuals.

Why it matters

Where this research is happening

• Icahn School of Medicine at Mount Sinai
  New York, United States Active

Researchers

• Principal investigator: Bhardwaj, Nina — Icahn School of Medicine at Mount Sinai
• Study coordinator: Bhardwaj, Nina

Related research

Other NIH-funded projects on the same topics.

• Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer

  This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.

  NIH research University of Chicago · Chicago, United States · NIH-11415083

• Behavioral tool to boost pre-test genetic counseling for Lynch syndrome families

  A risk-based program helps families at risk for Lynch syndrome get pre-test counseling more often, so they can learn about genetic testing and cancer prevention.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11393139

• Cancer vaccines for Lynch syndrome in a non-human primate model

  A researcher is testing a vaccine approach to help prevent Lynch syndrome–related cancers by training the immune system to recognize cancer-causing changes in the colon using a primate model.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11378426

• Neoantigen vaccine for Lynch syndrome immune interception

  A study to test a vaccine that teaches the immune system to recognize cancer-causing mutations in people with Lynch syndrome.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11223985

• Personalized colorectal cancer screening for people with Lynch syndrome

  This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11212167

• Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome

  This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.

  NIH research University of Chicago · Chicago, United States · NIH-11184230

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.