Improving colorectal cancer screening for people with Lynch Syndrome
Official title: Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype
Funded at Columbia University Health Sciences · NIH-10894888 · Data updated 2026-11-12
This study is looking to improve colorectal cancer screening for people with Lynch Syndrome by creating personalized recommendations based on their unique genetic makeup, so they can get the right care without unnecessary procedures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $353,665 |
| NIH project number | 5R01CA257333-04 |
| Project ID | NIH-10894888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lynch Syndrome who are at high risk for colorectal cancer.
✕Less likely to help
Patients without Lynch Syndrome or those at average risk for colorectal cancer may not benefit from this research.
What this research studies
This research aims to enhance colorectal cancer (CRC) screening strategies specifically for individuals with Lynch Syndrome, a genetic condition that significantly increases the risk of developing CRC. The study will investigate how to tailor screening recommendations based on the specific genetic profile of each patient, rather than applying a uniform approach. By analyzing the varying risks associated with different genotypes, the research seeks to reduce unnecessary procedures and improve the quality of life for patients. The findings could lead to more personalized and effective surveillance strategies that align with individual risk levels.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized colorectal cancer screening, reducing unnecessary procedures and improving patient quality of life.
How similar studies have gone: Previous research has shown that personalized screening approaches can improve outcomes in other hereditary cancer syndromes, suggesting potential success for this tailored strategy.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Hur, Chin — Columbia University Health Sciences
- Study coordinator: Hur, Chin
Related research
Other NIH-funded projects on the same topics.
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Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
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Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
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Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
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Personalized colonoscopy schedule for people with Lynch syndrome
This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.
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Improving colorectal cancer screening for people with Lynch syndrome
This study is looking at how to improve cancer check-ups for people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer, so they can catch it early and have better outcomes, especially focusing on making sure everyone, including Black individuals who are diagnosed younger, gets the screen
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Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests
This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.