Improving colorectal cancer screening for people with Lynch syndrome
Official title: Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype
Funded at Columbia University Health Sciences · NIH-11047374 · Data updated 2026-11-12
This study is looking at how to improve cancer check-ups for people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer, so they can catch it early and have better outcomes, especially focusing on making sure everyone, including Black individuals who are diagnosed younger, gets the screenings they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $70,872 |
| NIH project number | 3R01CA257333-04S1 |
| Project ID | NIH-11047374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lynch syndrome who are at increased risk for early-onset colorectal cancer.
✕Less likely to help
Patients without Lynch syndrome or those who do not have a family history of colorectal cancer may not benefit from this research.
What this research studies
This research focuses on enhancing colorectal cancer surveillance strategies specifically for individuals with Lynch syndrome, a genetic condition that increases cancer risk. By analyzing genetic factors and tailoring screening approaches, the study aims to identify the most effective methods for early detection of colorectal cancer. The goal is to improve patient outcomes by ensuring that those at higher risk receive appropriate and timely screenings, ultimately leading to better survival rates. The research also addresses disparities in screening adherence among different populations, particularly Black individuals who are often diagnosed at younger ages.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized colorectal cancer screening strategies, significantly improving early detection and survival rates for at-risk patients.
How similar studies have gone: Previous research has shown that tailored screening approaches can improve adherence and outcomes in cancer prevention, suggesting that this study builds on established successful strategies.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Hur, Chin — Columbia University Health Sciences
- Study coordinator: Hur, Chin
Related research
Other NIH-funded projects on the same topics.
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Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
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Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
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Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
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Personalized colonoscopy schedule for people with Lynch syndrome
This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.
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Improving colorectal cancer screening for people with Lynch Syndrome
This study is looking to improve colorectal cancer screening for people with Lynch Syndrome by creating personalized recommendations based on their unique genetic makeup, so they can get the right care without unnecessary procedures.
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Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests
This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.