Developing a liquid biopsy protocol for cancer research at Princess Margaret

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This initiative aims to establish a standardized liquid biopsy protocol at the Princess Margaret Cancer Centre, facilitating the collection of blood samples and archived tumor specimens for future research. By analyzing circulating cell-free nucleic acids (cfNA), including cfDNA and cfRNA, the study seeks to provide valuable diagnostic and prognostic insights throughout a patient's cancer journey. The protocol will enable non-invasive monitoring of tumor progression and treatment response over time, enhancing the understanding of cancer dynamics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with either histological confirmation of a solid tumor or hematological malignancy, OR patients identified as high-risk for cancer (based on identified aberration in cancer predisposition gene or on hormonal and/or family history without known aberration).
2. Patient must be ≥ 18 years old.
3. All patients must have signed and dated an informed consent form for this LIBERATE study.
4. If patients are being co-consented for a separate primary research study listed in Appendix I, they must fulfill the eligibility criteria for that separate primary research study. If there is a discrepancy in the eligibility criteria between protocols, the separate primary research study's criteria take precedence.

Exclusion Criteria:

None

Where it's running

• Princess Margaret Cancer Centre
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Lillian Siu, MD — Princess Margaret Cancer Centre
• Study coordinator: Celeste Yu, MSc
• Email: Celeste.Yu@uhn.ca
• Phone: 416-946-4501

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.