Genetic testing for hereditary cancer in Switzerland

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on cascade genetic testing for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) in Switzerland. It aims to identify and test family members of known mutation carriers to determine if they are also carriers of genetic mutations associated with these cancers. By improving access to genetic counseling and testing, the study seeks to enhance early detection and management of cancer risks among asymptomatic relatives. The methodology involves a coordinated approach to genetic screening and communication among family members.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Carrier of a mutation associated with HBOC or LS
2. Have at least one living blood relative
3. Men and women
4. 18 years old and older
5. Mentally and physically able to provide informed consent
6. Can read and speak German or French or Italian or English
7. Currently living in Switzerland.

Exclusion Criteria:

1. Carriers of unclassified variants (VUS) in BRCA1, BRCA2 or MLH1, MSH2, MSH6, PMS2, EPCAM genes
2. Not living in Switzerland
3. Patients who are critically ill and cannot complete the CASCADE survey
4. Participants who are institutionalized (e.g., nursing homes) or incarcerated

Where it's running

• Hôpital du Jura Service d'Oncologie
  Delémont, Canton of Jura, Switzerland Recruiting
• University Hospital Basel
  Basel, Switzerland Recruiting
• Istituto Oncologico della Zvizzera Italiana
  Bellinzona, Switzerland Recruiting
• Universitatklinik fur Medizinische Onkologie, Inselspital
  Bern, Switzerland Recruiting
• Unite d'Oncogenetique et de Prevention des Cancers
  Geneva, Switzerland Recruiting
• HFR Fribourg - Hôpital Cantonal
  Fribourg, Canton of Fribourg, Switzerland Not yet recruiting

Study contacts

• Principal investigator: Maria C Katapodi, PhD — University of Basel
• Study coordinator: Maria C Katapodi, PhD
• Email: maria.katapodi@unibas.ch
• Phone: ++41791095163

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.