How immune factors influence cancer development in Lynch Syndrome
Official title: Immune determinants modulating cancer development in Lynch Syndrome
Funded at Icahn School of Medicine at Mount Sinai · NIH-11114039 · Data updated 2026-11-12
This study is looking at how the immune system works in people with Lynch Syndrome, a genetic condition that raises the risk of cancer, to find better ways to prevent and treat cancer using new therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $836,028 |
| NIH project number | 5UG3CA290517-02 |
| Project ID | NIH-11114039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Lynch Syndrome who are at risk for developing certain types of cancer.
✕Less likely to help
Patients without Lynch Syndrome or those who do not have a hereditary predisposition to cancer may not benefit from this research.
What this research studies
This research investigates the immune mechanisms that affect cancer development in individuals with Lynch Syndrome, a hereditary condition that increases cancer risk. The study focuses on the role of specific mutations and immune responses in tumors associated with Lynch Syndrome, particularly how these factors may enhance the effectiveness of immune checkpoint inhibitors. By analyzing the immune profiles and tumor characteristics, the research aims to identify potential strategies for cancer prevention and treatment tailored to patients with this syndrome.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer prevention strategies and more effective treatments for patients with Lynch Syndrome.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in cancer, particularly in patients with high microsatellite instability, indicating that this approach has potential for success.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Bhardwaj, Nina — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bhardwaj, Nina
Related research
Other NIH-funded projects on the same topics.
-
Immune clues to prevent cancer in Lynch Syndrome
A study exploring how immune signals and shared neoantigens in Lynch Syndrome could help prevent cancer by training the immune system to recognize and fight premalignant lesions.
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Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
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Behavioral tool to boost pre-test genetic counseling for Lynch syndrome families
A risk-based program helps families at risk for Lynch syndrome get pre-test counseling more often, so they can learn about genetic testing and cancer prevention.
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Cancer vaccines for Lynch syndrome in a non-human primate model
A researcher is testing a vaccine approach to help prevent Lynch syndrome–related cancers by training the immune system to recognize cancer-causing changes in the colon using a primate model.
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Neoantigen vaccine for Lynch syndrome immune interception
A study to test a vaccine that teaches the immune system to recognize cancer-causing mutations in people with Lynch syndrome.
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Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.