Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11184230 on NIH RePORTER |
What this research studies
If you join, you'll provide a stool sample for a FIT before your routine colonoscopy at one of several centers and researchers will compare FIT results with what the colonoscopy finds to see how well FIT detects cancers or precancerous polyps. You'll be asked about your attitudes and how acceptable a non-invasive test would be as part of surveillance. The team will collect and store clinical samples in a new US Lynch syndrome biobank for future biomarker studies. They will also use computer modeling to design personalized surveillance plans that combine FIT and colonoscopy based on gene and age-specific risk.
Who could benefit from this research
Good fit: Adults (21 years and older) with genetically confirmed Lynch syndrome who are scheduled for routine colonoscopy surveillance are ideal candidates.
Not a fit: People without Lynch syndrome, those unwilling to provide stool samples or travel to a study site, or those with urgent symptoms requiring immediate diagnostic colonoscopy may not benefit from this approach.
Why it matters
Potential benefit: If successful, this could reduce how often people with Lynch syndrome need invasive colonoscopies and help tailor surveillance to each person's risk.
How similar studies have performed: FIT is effective for average-risk colorectal cancer screening, but using FIT to guide surveillance specifically in Lynch syndrome is largely untested.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kupfer, Sonia — University of Chicago
- Study coordinator: Kupfer, Sonia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.