Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
Official title: FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
Funded at University of Chicago · NIH-11184230 · Data updated 2026-11-12
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $669,912 |
| NIH project number | 5R01CA287257-02 |
| Project ID | NIH-11184230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21 years and older) with genetically confirmed Lynch syndrome who are scheduled for routine colonoscopy surveillance are ideal candidates.
✕Less likely to help
People without Lynch syndrome, those unwilling to provide stool samples or travel to a study site, or those with urgent symptoms requiring immediate diagnostic colonoscopy may not benefit from this approach.
What this research studies
If you join, you'll provide a stool sample for a FIT before your routine colonoscopy at one of several centers and researchers will compare FIT results with what the colonoscopy finds to see how well FIT detects cancers or precancerous polyps. You'll be asked about your attitudes and how acceptable a non-invasive test would be as part of surveillance. The team will collect and store clinical samples in a new US Lynch syndrome biobank for future biomarker studies. They will also use computer modeling to design personalized surveillance plans that combine FIT and colonoscopy based on gene and age-specific risk.
Why it matters
Potential benefit: If successful, this could reduce how often people with Lynch syndrome need invasive colonoscopies and help tailor surveillance to each person's risk.
How similar studies have gone: FIT is effective for average-risk colorectal cancer screening, but using FIT to guide surveillance specifically in Lynch syndrome is largely untested.
Where this research is happening
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University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kupfer, Sonia — University of Chicago
- Study coordinator: Kupfer, Sonia
Related research
Other NIH-funded projects on the same topics.
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Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
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Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
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Personalized colonoscopy schedule for people with Lynch syndrome
This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.
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Improving colorectal cancer screening for people with Lynch syndrome
This study is looking at how to improve cancer check-ups for people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer, so they can catch it early and have better outcomes, especially focusing on making sure everyone, including Black individuals who are diagnosed younger, gets the screen
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Improving colorectal cancer screening for people with Lynch Syndrome
This study is looking to improve colorectal cancer screening for people with Lynch Syndrome by creating personalized recommendations based on their unique genetic makeup, so they can get the right care without unnecessary procedures.
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Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests
This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.