Understanding genetic causes of neuroendocrine tumors in Mexican patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to identify the genetic defects associated with neuroendocrine neoplasms (NENs) in a large cohort of Mexican patients. Utilizing three different genetic testing methods, the study will explore both inherited and non-inherited genetic changes that may contribute to the development of these tumors. NENs can vary significantly in their clinical behavior, and understanding their genetic basis could lead to better-targeted treatments. The research addresses a critical gap in genetic testing availability in Mexico, where such tests are not widely accessible.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adult patients with a new or previous clinical diagnosis of any of the following conditions:

* Isolated NENs with sporadic presentation, including bronchopulmonary NENs, gastrointestinal NENs, medullary thyroid carcinoma, pancreatic NENs, paragangliomas, pheochromocytomas, pituitary neuroendocrine tumors, and primary hyperparathyroidism.
* Familial isolated NENs, including familial isolated pituitary adenoma, familial pheochromocytomas and paragangliomas, familial primary hyperparathyroidism, familial gastrointestinal stromal tumors and X-linked acrogigantism.
* Clinical syndromes encompassing NENs, with familial or sporadic presentation, including Carney complex, Carney-Stratakis syndrome, Carney triad, Cowden syndrome, DICER1 syndrome, Li-Fraumeni syndrome, Lynch syndrome, multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 2, multiple endocrine neoplasia type 4, neurofibromatosis type 1, Pacak-Zhuang syndrome, paraganglioma, pheochromocytoma and pituitary adenoma syndrome, tuberous sclerosis complex, Von Hippel Lindau syndrome.

Exclusion criteria:

* Age \<18 years.
* Refusal to give informed consent.

Where it's running

• Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
  Mexico City, Mexico City, Mexico Recruiting
• Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
  Mexico City, Mexico City, Mexico Recruiting
• Red de Apoyo a la Investigación, Coordinación de la Investigación Científica, Universidad Nacional Autónoma de México
  Mexico City, Mexico City, Mexico Recruiting

Study contacts

• Principal investigator: Laura C Hernández Ramírez, MD, PhD — Universidad Nacional Autonoma de Mexico
• Study coordinator: Laura C Hernández Ramírez, MD, PhD
• Email: laura.hernandez@cic.unam.mx
• Phone: +525554870900

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.