Investigating genetic factors in childhood cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the hereditary factors contributing to various childhood cancers by collecting blood, saliva, and tissue samples from participants. It focuses on families with a history of cancer, particularly those with members diagnosed at a young age. Participants will provide medical and family histories, and their biological samples will be analyzed for genetic changes associated with cancer predisposition. The study will also involve annual follow-ups to update health information and family history.

Why it matters

Who can join: the full rules

NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility criteria for this study as shown below, you may enroll regardless of the results of your clinical genetic testing.

DEFINITION OF FAMILIAR CANCER FOR THIS PROTOCOL:

In this protocol, the definition of "Familial Cancer" is met if any of the following is present:

* An individual with a history of cancer diagnosed under 26 years of age who has at least one first, second or third degree relative with a history of cancer diagnosed under 51 years of age; OR
* An individual who has been diagnosed with more than one cancer, at least one of which was diagnosed under 26 years of age; OR
* An individual with a clinical or molecular diagnosis of a known cancer predisposition syndrome; OR
* An individual with a congenital cancer diagnosed before 6 months of age; OR
* An individual with a rare pediatric cancer or tumor diagnosed before 26 years of age

º Excluding human papilloma virus-associated cervical cancer and non-melanoma skin cancer occurring in adults.

INCLUSION CRITERIA:

* An individual who meets this protocol's definition of "Familial Cancer," as above.
* Biologic relatives of an individual meeting this protocol's definition of "Familial Cancer," who are either affected or unaffected by cancer.

EXCLUSION CRITERIA:

* An inability or unwillingness of the research participant or his/her legally authorized representative (LAR) to provide written informed consent.
* The participant has received allogeneic bone marrow transplantation and has NO pre-transplant germline (cancer-unaffected) DNA available AND is unwilling to provide a skin sample.

Where it's running

• St. Jude Children's Research Hospital
  Memphis, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Kim E. Nichols, MD — St. Jude Children's Research Hospital
• Study coordinator: Kim E. Nichols, MD
• Email: referralinfo@stjude.org
• Phone: 888-226-4343

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.