Personalized colonoscopy schedule for people with Lynch syndrome
Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11167473
This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11167473 on ClinicalTrials.gov |
What this research studies
You would hear how colorectal cancer risk differs depending on which Lynch syndrome gene you carry and see screening plans that reflect that risk. Researchers will combine medical records, cancer outcomes, and genetic information to model lifetime cancer risk and how often colonoscopies would be needed. They will compare harms and benefits like cancer cases prevented, deaths avoided, and the number of colonoscopies people would undergo. The goal is to suggest less frequent checks for lower-risk genes and focused surveillance for higher-risk genes so care is safer and easier to live with.
Who could benefit from this research
Good fit: Adults with a confirmed Lynch syndrome pathogenic variant (for example MLH1, MSH2, MSH6, PMS2, or EPCAM) who are receiving or planning colorectal surveillance are the ideal candidates.
Not a fit: People without a confirmed Lynch syndrome gene or those with complex prior colorectal cancer history or other medical reasons requiring individualized follow-up may not benefit from generalized genotype-based schedules.
Why it matters
Potential benefit: If successful, this could lower the number of lifetime colonoscopies for many people with Lynch syndrome while maintaining strong protection against colorectal cancer.
How similar studies have performed: Previous research has documented different colorectal cancer risks by Lynch gene and modeling work supports genotype-tailored screening, but large prospective trials of personalized schedules are limited.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUR, CHIN — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: HUR, CHIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Control, Cancer Control Science, Cancer Model, CancerModel, Cancers