Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
Official title: FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial
Funded at University of Chicago · NIH-11415083 · Data updated 2026-11-12
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,015,182 |
| NIH project number | 4R01CA287257-03 |
| Project ID | NIH-11415083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Lynch syndrome who are undergoing colonoscopy surveillance.
✕Less likely to help
People without Lynch syndrome or those not undergoing colonoscopy surveillance may not benefit.
What this research studies
If you have Lynch syndrome, you face a higher risk of colorectal cancer and current surveillance relies heavily on frequent colonoscopies. The study will look at how well the FIT poop test works when used with colonoscopy in LS patients, and how people feel about using noninvasive tests. Researchers will also use the data to build personalized surveillance strategies and create a well-annotated LS biobank for future biomarker studies. The study is multicenter and prospective, enrolling adults to see how best to combine tests to improve safety and practicality.
Why it matters
Potential benefit: If successful, this approach could reduce unnecessary invasive procedures while maintaining cancer detection, improving quality of life and accessibility of surveillance.
How similar studies have gone: Previous work suggests noninvasive tests can complement colonoscopy, but this exact approach in LS is being tested.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kupfer, Sonia — University of Chicago
- Study coordinator: Kupfer, Sonia
Related research
Other NIH-funded projects on the same topics.
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Personalized colorectal cancer screening for people with Lynch syndrome
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
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Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
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Personalized colonoscopy schedule for people with Lynch syndrome
This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.
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Improving colorectal cancer screening for people with Lynch syndrome
This study is looking at how to improve cancer check-ups for people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer, so they can catch it early and have better outcomes, especially focusing on making sure everyone, including Black individuals who are diagnosed younger, gets the screen
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Improving colorectal cancer screening for people with Lynch Syndrome
This study is looking to improve colorectal cancer screening for people with Lynch Syndrome by creating personalized recommendations based on their unique genetic makeup, so they can get the right care without unnecessary procedures.
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Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests
This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.