Personalized colorectal cancer screening for people with Lynch syndrome
Official title: Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype
Funded at Columbia University Health Sciences · NIH-11212167 · Data updated 2026-11-12
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $70,872 |
| NIH project number | 3R01CA257333-05S1 |
| Project ID | NIH-11212167 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with a confirmed pathogenic variant in a Lynch syndrome gene (for example MLH1, MSH2, MSH6, PMS2, or EPCAM) who are candidates for colorectal cancer surveillance would be ideal.
✕Less likely to help
People without a confirmed Lynch syndrome genetic diagnosis or those already being treated for colorectal cancer are unlikely to benefit from this surveillance-focused work.
What this research studies
You would be part of work that looks at how different Lynch syndrome genes change your risk of colorectal cancer and how often you actually need colonoscopies. The team will use genetic and medical records from people with Lynch syndrome and build computer models to compare screening schedules tailored to each gene. They will estimate likely cancer cases, deaths, number of colonoscopies, and effects on quality of life for each schedule. Researchers will also gather input on whether patients and doctors find the tailored plans acceptable.
Why it matters
Potential benefit: If successful, this could lower unnecessary colonoscopies for some people while keeping cancer risk low and improving quality of life.
How similar studies have gone: Prior research shows different Lynch genes carry different cancer risks, but personalized surveillance schedules have not been widely tested, so this approach is partly novel though grounded in existing evidence.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Hur, Chin — Columbia University Health Sciences
- Study coordinator: Hur, Chin
Related research
Other NIH-funded projects on the same topics.
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Personalized, Noninvasive Surveillance for Lynch Syndrome Colorectal Cancer
This project tests a noninvasive fecal test (FIT) alongside colonoscopy to tailor colorectal cancer surveillance for people with Lynch syndrome.
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Stool blood testing (FIT) to guide colonoscopy checks for people with Lynch syndrome
This project will test whether a simple stool blood test (FIT) can be used alongside colonoscopies to make cancer screening easier and more personalized for adults with Lynch syndrome.
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Personalized colonoscopy schedule for people with Lynch syndrome
This project aims to find colonoscopy schedules matched to each Lynch syndrome gene so people can avoid extra procedures while still preventing colorectal cancer.
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Improving colorectal cancer screening for people with Lynch syndrome
This study is looking at how to improve cancer check-ups for people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer, so they can catch it early and have better outcomes, especially focusing on making sure everyone, including Black individuals who are diagnosed younger, gets the screen
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Improving colorectal cancer screening for people with Lynch Syndrome
This study is looking to improve colorectal cancer screening for people with Lynch Syndrome by creating personalized recommendations based on their unique genetic makeup, so they can get the right care without unnecessary procedures.
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Improving colorectal cancer screening for Lynch syndrome patients using noninvasive tests
This study is looking at how we can make regular check-ups for colorectal cancer easier and more comfortable for people with Lynch syndrome by using simple tests like the FIT along with regular colonoscopies, to see if this combination works well and is accepted by patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.