Personalized colorectal cancer screening for people with Lynch syndrome
Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype
This project aims to find the best colonoscopy schedule for people with Lynch syndrome based on their specific gene.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11212167 on NIH RePORTER |
What this research studies
You would be part of work that looks at how different Lynch syndrome genes change your risk of colorectal cancer and how often you actually need colonoscopies. The team will use genetic and medical records from people with Lynch syndrome and build computer models to compare screening schedules tailored to each gene. They will estimate likely cancer cases, deaths, number of colonoscopies, and effects on quality of life for each schedule. Researchers will also gather input on whether patients and doctors find the tailored plans acceptable.
Who could benefit from this research
Good fit: People with a confirmed pathogenic variant in a Lynch syndrome gene (for example MLH1, MSH2, MSH6, PMS2, or EPCAM) who are candidates for colorectal cancer surveillance would be ideal.
Not a fit: People without a confirmed Lynch syndrome genetic diagnosis or those already being treated for colorectal cancer are unlikely to benefit from this surveillance-focused work.
Why it matters
Potential benefit: If successful, this could lower unnecessary colonoscopies for some people while keeping cancer risk low and improving quality of life.
How similar studies have performed: Prior research shows different Lynch genes carry different cancer risks, but personalized surveillance schedules have not been widely tested, so this approach is partly novel though grounded in existing evidence.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Hur, Chin — Columbia University Health Sciences
- Study coordinator: Hur, Chin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.