Vaginal self-swabs and a health questionnaire to check uterine cancer risk in people with Lynch syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study enrolls people aged 30 or older with genetically confirmed Lynch syndrome who retain their uterus and are not pregnant, excluding those with prior endometrial cancer, endometrial hyperplasia, pelvic radiation, or endometrial ablation. Participants complete a health and symptom questionnaire, perform at-home self-collection of vaginal DNA and microbiome swabs, measure vaginal pH, and complete brief surveys at collection and study end. Investigators will measure how acceptable and feasible self-collection is and analyze vaginal DNA mutations and microbiome data to see whether they align with existing genetic or pathology findings and predict cancer risk. The project also explores whether a cancer risk model used in the general population can help identify higher-risk individuals among Lynch carriers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with Lynch syndrome (confirmed by genetic testing).
* Have an intact uterus.
* Age 30 years or older.

Exclusion Criteria:

* History of endometrial cancer or endometrial hyperplasia.
* History of pelvic radiation or endometrial ablation.
* Pregnant at the time of study enrolment or during the study.

Where it's running

• VGH Research Pavilion
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Study coordinator: Aline Talhouk, PhD
• Email: a.talhouk@ubc.ca
• Phone: 604-875-4111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.