Condition
HIV-1-infection clinical trials and research
As of November 12, 2026, Find a Trial lists 41 HIV-1-infection clinical trials that are recruiting, at sites in 31 countries (most in United States (22), South Africa (4), Italy (3)). By phase: Phase 2 (7), Phase 1 (6), Phase 4 (6), Phase 3 (4). The most active sponsors are Gilead Sciences (7), University of California, San Francisco (2), International Maternal Pediatric Adolescent AIDS Clinical Trials Group (2). There are also 40 NIH-funded research projects on HIV-1-infection, with $30.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 41Clinical trials
- 40NIH research projects
- 31Countries
Newest HIV-1-infection clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Weekly long-acting HIV-1 meds switch for people with undetectable virus | Phase 2 | Ft. Pierce, Florida and 1 other locations | Recruiting | Sep 25, 2026 |
| HIV in Hong Kong: patterns, transmission, and burden over time | — | North Point | Recruiting | Jul 24, 2026 |
| GS-0415 safety and PK in people with HIV on ART | Phase 1 | Los Angeles, California and 15 other locations | Recruiting | Jul 22, 2026 |
| Gilead study of GS-3242 with Lenacapavir for people starting HIV treatment compared with Biktarvy | Phase 2/3 | Torrance, California and 20 other locations | Recruiting | Jul 16, 2026 |
| RNA-based vaccine BNT168 safety and immune response in adults with or without HIV | Phase 1 | Houston, Texas and 3 other locations | Recruiting | Jul 13, 2026 |
| Long-acting LEN/TAB/ZAB regimen vs daily HIV meds in adults with suppressed HIV-1 | Phase 3 | Berkeley, Michigan and 1 other locations | Recruiting | Jul 6, 2026 |
| Switch to GS-3242 plus Lenacapavir vs Biktarvy in virologically suppressed people with HIV-1 | Phase 2 | Phoenix, Arizona and 58 other locations | Recruiting | Jun 12, 2026 |
| How HIV Treatment Changes Affect Hidden Drug Resistance | — | Hong Kong, Hong Kong | Recruiting | Jun 12, 2026 |
| Long-acting cabotegravir and rilpivirine in pregnancy | Phase 4 | La Jolla, California and 9 other locations | Recruiting | Jun 10, 2026 |
| Dolutegravir/Lamivudine in treatment-naïve pregnant women | Phase 4 | Ciudad Autónoma de Buenos Aires, Buenos Aires and 9 other locations | Recruiting | Jun 1, 2026 |
All recruiting trials (41)
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Weekly long-acting HIV-1 meds switch for people with undetectable virus
This study tests whether switching to weekly oral long-acting HIV medicines works as well as staying on current daily pills for people with HIV who already have an undetectable viral load.
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HIV in Hong Kong: patterns, transmission, and burden over time
This project tests how HIV-1 infections in Hong Kong have changed over several years by following newly diagnosed adults and analyzing their subtypes, transmission links, and community burden.
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GS-0415 safety and PK in people with HIV on ART
This study tests GS-0415 in adults with HIV who are on stable ART to see if it is safe, tolerable, and how the drug behaves in the body.
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Gilead study of GS-3242 with Lenacapavir for people starting HIV treatment compared with Biktarvy
This study tests whether injecting GS-3242 with Lenacapavir can work as well as Biktarvy for people newly starting HIV treatment.
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RNA-based vaccine BNT168 safety and immune response in adults with or without HIV
A first-in-human study tests whether the RNA vaccine BNT168 is safe and can trigger immune responses in adults both with and without HIV.
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Long-acting LEN/TAB/ZAB regimen vs daily HIV meds in adults with suppressed HIV-1
This study tests whether switching to an injectable, long-acting combination (lenacapavir, teropavimab, zinlirvimab) can keep HIV-1 under control in adults who are already virally suppressed on stable oral therapy.
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Switch to GS-3242 plus Lenacapavir vs Biktarvy in virologically suppressed people with HIV-1
This study tests whether switching to GS-3242 with Lenacapavir can maintain viral suppression better than staying on Biktarvy in people living with HIV-1 who are already suppressed.
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How HIV Treatment Changes Affect Hidden Drug Resistance
Researchers will see if changing HIV treatment in people with fully suppressed virus reveals hidden drug resistance in proviral DNA.
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Long-acting cabotegravir and rilpivirine in pregnancy
This study tests whether long-acting injectable HIV medicines given every 4 weeks are safe and effective for pregnant people with HIV and their babies.
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Dolutegravir/Lamivudine in treatment-naïve pregnant women
This study tests a two-drug HIV regimen (dolutegravir and lamivudine) in pregnant people who start HIV treatment to see if it keeps the virus suppressed and prevents transmission to the baby.
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IAP086 first-in-human single-dose safety study in people with HIV on ART
This first-in-human trial tests a single dose of IAP086 to see if it is safe and tolerable in adults with HIV who are on stable antiretroviral therapy.
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TruPlex rapid test for HIV, Hepatitis B, and syphilis performance and usability
This project will test whether the TruPlex rapid test can accurately detect HIV, hepatitis B, and syphilis when used by trained healthcare workers on adults getting tested for these infections.
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Restarting HIV treatment with a single-pill regimen (B/F/TAF) after a treatment gap
This study tests whether quickly restarting ART with the single-pill regimen B/F/TAF is safe and effective for people with HIV who have had a treatment interruption of at least 12 weeks.
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Restarting HIV treatment with a single-pill regimen (B/F/TAF) after a treatment gap
This study tests whether quickly restarting ART with the single-pill regimen B/F/TAF is safe and effective for people with HIV who have had a treatment interruption of at least 12 weeks.
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Safety and blood activity of the antibody BNT351 in adults with and without HIV
This study will test whether one dose of the antibody BNT351 is safe, how long it stays in the blood, and if it lowers HIV levels in adults with and without HIV.
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Doravirine-based regimen started quickly in HIV-1 infection
This study tests whether a doravirine/lamivudine/tenofovir combination started rapidly is effective and safe for adults with HIV-1 who have not been treated before.
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Single-dose CL-197 capsules for adults with HIV-1 infection
This trial will test if a single dose of CL-197 capsules is safe and lowers HIV-1 levels in adults who have never taken HIV medications.
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Lactation and infant feeding practices among U.S. women living with HIV
See how pregnant and postpartum women with HIV in the United States make infant feeding choices and what outcomes their infants experience.
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ICONA Prevention Program for People Using PrEP in Italy
This program will follow HIV-negative adults in Italy who are starting or already using PrEP to see how well PrEP prevents HIV, how tolerable it is, and what helps or hinders people from staying on it.
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MucoCept-CVN: a vaginal Lactobacillus product to help prevent HIV
This trial will test whether a modified vaginal Lactobacillus that produces an anti‑HIV protein is safe and can colonize the vagina in healthy premenopausal women.
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IT-guided HIV screening and prevention in dental clinics
This project will test whether an electronic alert plus either the usual dental team or an added care navigator helps dental teams offer HIV testing and prevention to dental patients.
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Improving coronary blood flow in women with HIV and diabetes or chronic kidney disease
This study will test whether referring women with HIV and diabetes or chronic kidney disease to a specialist so they can be considered for SGLT2 inhibitor medicine, compared with health education alone, improves blood flow in their hearts.
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Comparing two HIV treatment regimens for maintaining viral suppression
This study is testing whether two different HIV treatment combinations can help people who have their virus under control stay healthy without using certain types of medications.
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Long-acting Lenacapavir for treating HIV-1 in adolescents and children
This study is testing a new long-acting HIV treatment called lenacapavir to see if it works better for adolescents and children who have had problems with their current medications.
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Best way to manage dolutegravir resistance in people with HIV
This trial will test whether staying on dolutegravir or switching to darunavir/ritonavir better controls HIV in people with dolutegravir-resistant virus and a viral load of 200 copies/mL or higher.
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Using caspofungin to treat Pneumocystis pneumonia in people with HIV.
This study is testing whether caspofungin can be a safer treatment for Pneumocystis pneumonia in people with HIV/AIDS compared to the usual medication.
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Therapy for HIV-positive individuals with hazardous drinking
This study is testing if a new therapy combined with a short alcohol intervention can help people with HIV who drink too much to reduce their alcohol use and improve their overall health.
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Tesamorelin plus exercise to improve physical function in older adults with HIV
This trial will test whether adding the drug tesamorelin to a structured exercise program helps improve strength and physical performance in adults aged 50–80 living with HIV who have abdominal obesity and early frailty.
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Survey to assess eligibility for infectious disease clinical trials
This study is trying to find out if people are eligible to join clinical trials for infectious diseases like HIV and vaccines by having them fill out a survey about their health and background.
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Providing ongoing access to HIV treatment for children and adolescents
This study is testing whether children and teens with HIV can keep getting their treatment or switch to a new combination therapy to ensure they stay healthy.
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Comparing doravirine and dolutegravir for treating HIV-1 in new patients
This study is testing if a new HIV treatment called doravirine works just as well as the standard treatment dolutegravir for people who are starting their first HIV therapy.
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Monitoring HIV drug resistance and treatment strategies in Eastern Europe and Russia
This study is trying to see how new HIV drugs work in people in Eastern Europe and Russia by looking at how drug resistance changes over time and how it affects treatment.
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Observing HIV control without medication
This study looks at people who have been able to control their HIV without medication to see how they do it and what keeps them healthy.
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Immuno-virological Evaluation of People Living with HIV
This study will test immune and viral factors in two groups of people with HIV who have been on stable ART for different lengths of time.
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Using Venetoclax to Target HIV-infected Cells in People on ART
This study is testing if a drug called venetoclax can help people living with HIV who are on treatment by targeting and killing HIV-infected cells to see if it improves their immune function and reduces the virus in their bodies.
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Investigating the HIV Infected Reservoir to Find a Cure
This study is trying to find ways to cure HIV by looking at the hidden virus in the blood of different groups of people living with HIV.
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Investigating how depression treatment affects gut health and brain function in people with HIV
This study is testing whether treating depression with therapy can improve gut health and brain function in people living with HIV.
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Testing a two-pill HIV treatment for patients switching from triple therapy
This study is testing if switching to a new two-pill HIV treatment can keep people with HIV healthy and undetectable after they’ve been on a stable three-pill regimen.
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Using Semaglutide to Help People with HIV Lose Weight
This study is testing if a weight loss medication called semaglutide can help people with HIV lose weight and improve their overall health.
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Registry of HIV-1 Patients with Drug Resistance
This study is tracking people with HIV-1 who have drug resistance to see how different treatments work for them over time.
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Imaging of a Radiolabeled Antibody for HIV-1
This study is testing a special imaging technique using a tiny dose of a radiolabeled antibody in people with HIV and healthy volunteers to see how it spreads in the body and if there are differences between the two groups.
NIH-funded research (40)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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BEAT-HIV: a collaborative effort to cure HIV with immunotherapy
A multi-institution study is testing a combination immunotherapy approach to achieve long-term HIV remission or cure for people on ART.
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Phosphatidylserine-targeting antibodies and T cell function in HIV-1 infection
This NIH grant will explore how antibodies that target phosphatidylserine affect immune cells in people living with HIV on ART.
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Ribosomal frameshifting in HIV-1 infection and its effects on inflammation and brain health
A study at the University of Rochester will explore how HIV-1 may change human cell machinery to boost its own replication and cause inflammation and brain-related problems.
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Targeting NLRP3 inflammasome to protect HIV patients from stroke
A small NIH grant will explore whether HIV infection makes stroke worse and whether blocking a brain inflammation pathway (NLRP3) could protect brain tissue.
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Reprogramming tissue immune cells (macrophages) to target hidden HIV
Trying small drug molecules to reprogram tissue immune cells so infected cells die and hidden HIV is reduced in people living with HIV.
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EHD4 protein and HIV-1 infection: a new potential antiviral target
A study to understand how the human protein EHD4 affects HIV-1 infection and whether it could be targeted to develop better antiviral therapies.
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Understanding Brain Cell Growth in People with HIV and Methamphetamine Exposure
This research explores how HIV and methamphetamine use together might change how new brain cells grow, aiming to understand related thinking problems.
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Elite controllers: learning how the body can cure HIV-1 naturally
Researchers are studying people who naturally control HIV-1 without drugs to uncover clues for a functional cure that could help others live without daily therapy.
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How host +TIP proteins attach to HIV's capsid during early infection
This project looks at whether certain human cell proteins called +TIPs attach to and change the HIV capsid during the virus's earliest steps, which might reveal new ways to block infection.
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How HIV and long-term HIV medicines affect brain circuits
This project is mapping how HIV infection and long-term antiretroviral medicines may change brain activity linked to thinking and memory in people with HIV.
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How FEZ proteins help HIV move inside human cells
This research looks at how proteins called FEZ help HIV travel inside human cells early after infection.
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Precision immune strategies to control HIV in babies and children
Trying immune-based treatments in infants, children, and teens with HIV to help their immune systems control the virus and possibly reduce lifelong medicine needs.
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Why some people naturally keep HIV under control
This project looks at why a small group of people called elite controllers keep HIV at undetectable levels without treatment, to help develop ways to silence the virus for others living with HIV.
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Understanding and Treating Brain Disorders in People with HIV
This work explores how a specific chemical byproduct might cause brain and nerve problems in people living with HIV, and tests new ways to reduce it.
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Understanding Gut Antibodies in HIV-1 Infection
This project looks at how special antibodies in the gut might help people living with HIV-1 stay healthier.
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Understanding the body's early response to HIV-1
This work explores how the body's natural defenses react right after HIV-1 infection to help develop better ways to prevent or treat the virus.
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Understanding why some people with HIV don't recover their immune cells
This research explores how gut bacteria might prevent some people with HIV from fully restoring their immune system, even with treatment.
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How HIV-1 infects CD4+ T cells through a process called macropinocytosis
This study is looking at how HIV-1 gets into important immune cells called CD4+ T cells and how a special process called macropinocytosis helps with this, so we can find new ways to fight HIV/AIDS.
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Understanding how HIV-1 moves inside cells during early infection
This study is looking at how the HIV virus moves inside cells to reach the nucleus, focusing on a special protein called FEZ1 that helps with this process, which could help us find new ways to treat HIV infections.
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Understanding how HIV-1 infects cells
This work aims to understand the very first steps of how the HIV-1 virus enters and infects human cells.
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BEAT-HIV: Combination Treatments to Cure HIV-1 Infection
This project looks for new ways to cure HIV-1 infection by combining different immune-boosting treatments.
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Investigating how CARD8 inflammasome affects HIV-1 infection
This study is looking at how a part of your immune system called CARD8 interacts with the HIV virus and how this could help us find better ways to treat people living with HIV by targeting hidden virus reservoirs.
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Effects of certain molecules on brain cell growth after methamphetamine use and HIV infection
This study is looking at how methamphetamine and HIV might affect the growth of new brain cells in adults, especially by exploring the role of certain molecules that help move brain cells around, with the hope of finding new ways to help people with HIV who also use meth.
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Investigating how certain proteins interact with HIV-1 during early infection
This study is looking at how certain proteins in our bodies interact with the HIV virus in its early stages, which could help scientists find new ways to treat HIV and improve care for patients.
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Investigating how HIV-1 infection and antiretroviral therapy affect brain function
This study is looking at how HIV-1 infection and the treatment for it can affect thinking and memory by using special imaging techniques on mice to see how their brains work, which could help us understand similar challenges in people living with HIV.
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Understanding how the immune system detects HIV-1 infection
This study is looking at how the body's first line of defense reacts to HIV-1 right after infection, using special mice to help understand which immune cells are involved, and the findings could help improve vaccines and treatments for people living with HIV.
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Investigating neurological disorders in people living with HIV
This study is looking at how a substance related to sugar breakdown might affect brain health in middle-aged people with HIV, using mice to see if lowering this substance can help improve their symptoms.
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Understanding how antibodies interact with the gut microbiome in HIV-1 infection
This study is looking at how a type of antibody called IgA helps keep the gut healthy for people living with HIV-1, by comparing gut samples from those with and without the virus to see how these antibodies work with gut bacteria and affect overall health.
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Exploring new ways to control HIV-1 infection in children
This study is exploring new ways to help kids and teens with HIV-1 by boosting their immune systems to better control the virus, aiming for a functional cure that doesn't require completely getting rid of it.
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Understanding how elite controllers manage HIV-1 infection without treatment
This study is looking at a special group of people called elite controllers who can keep HIV-1 at very low levels without any medication, and by exploring their unique genetics, we hope to find new ways to help others with HIV-1 manage the virus better or even find a cure.
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Investigating lung cancer risks in people with HIV-1 in Uganda and Tanzania
This study is looking at how being infected with HIV-1 might increase the chances of getting lung cancer, especially in Uganda and Tanzania, and it wants to find out what other factors, like smoking and the environment, play a role so that we can come up with better ways to prevent and catch lung cancer early for peopl
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Investigating lung cancer and its link to HIV-1 in East Africa
This study is looking at how lung cancer and HIV-1 infection are connected in East Africa, aiming to improve how lung cancer is diagnosed and treated, especially for those who might also have tuberculosis, so that patients can get the right care they need.
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Understanding how cannabinoids affect HIV-1 infection and inflammation
This study is looking at how cannabinoids might help reduce inflammation in people living with HIV by exploring their effects on certain immune cells, and it aims to find new ways to manage inflammation even when HIV treatment is working.
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Finding a cure for HIV-1 infection through mentoring
This study is all about helping new scientists and doctors learn how to conduct research that could lead to better treatments for HIV, using real patient cells to find new ways to fight the virus.
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Understanding heart failure in people with HIV-1 infection
This study is looking at how a harmful substance in the body might lead to heart problems in people with long-term HIV, and it hopes to find new ways to help treat these heart issues.
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New methods to improve immune cell functions for clearing HIV-1 infection
This study is looking at how certain antibodies can help your immune system better fight off HIV-infected cells while you're on treatment, with the hope of finding new ways to help people with HIV live healthier lives.
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Investigating how masculinizing hormone therapy affects HIV-1 risk in transgender men
This study is looking at how testosterone therapy affects transgender men and whether it changes their risk of getting HIV, helping us learn more about their sexual health and safety.
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Investigating how HIV drugs cross the blood-brain barrier
This study is looking at how well certain HIV medications can get into the brain to fight the virus, with the goal of finding better ways to help people living with HIV-1.
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Investigating how different injectable contraceptives affect HIV-1 infection risk in women.
This study is looking at how two types of birth control shots might affect the risk of getting HIV-1 in young women in sub-Saharan Africa, so we can better understand their safety and help keep women healthy.
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Tracking HIV treatment effects in the brain using advanced imaging techniques
This study is looking at how HIV medications affect the brain using a special type of MRI that can see important brain chemicals, helping us understand how these drugs work and improve brain health for people living with HIV.
Related topics
Quick answers
How many HIV-1-infection clinical trials are recruiting right now?
41, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 31 countries. The most sites are in United States (22 trials), South Africa (4 trials), Italy (3 trials), Germany (3 trials), Argentina (3 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 7, Phase 1: 6, Phase 4: 6, Phase 3: 4. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.