Finding a cure for HIV-1 infection through mentoring
Official title: Mentoring in patient-oriented research to finding a cure for HIV-1 infection
Funded at Brigham and Women's Hospital · NIH-10877808 · Data updated 2026-11-12
This study is all about helping new scientists and doctors learn how to conduct research that could lead to better treatments for HIV, using real patient cells to find new ways to fight the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 13, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $192,097 |
| NIH project number | 5K24AI155233-04 |
| Project ID | NIH-10877808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older living with HIV-1 who are interested in participating in clinical trials.
✕Less likely to help
Patients who are not infected with HIV-1 or those who are not eligible for clinical trials may not benefit from this research.
What this research studies
This research focuses on mentoring emerging scientists and physicians in patient-oriented studies aimed at finding a cure for HIV-1 infection. It involves conducting clinical trials and molecular studies using patient-derived cells to explore innovative therapeutic strategies. The program emphasizes training in the design and implementation of interventional trials, providing a platform for developing new approaches to reduce HIV-1 reservoirs. Participants may engage in cutting-edge research that could lead to significant advancements in HIV treatment.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in curing HIV-1 infection, improving the lives of those affected by the virus.
How similar studies have gone: Previous research in similar areas has shown promise in developing therapeutic strategies for HIV-1 eradication, indicating a potential for success in this approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Lichterfeld, Mathias — Brigham and Women's Hospital
- Study coordinator: Lichterfeld, Mathias
Related research
Other NIH-funded projects on the same topics.
-
BEAT-HIV: a collaborative effort to cure HIV with immunotherapy
A multi-institution study is testing a combination immunotherapy approach to achieve long-term HIV remission or cure for people on ART.
-
Phosphatidylserine-targeting antibodies and T cell function in HIV-1 infection
This NIH grant will explore how antibodies that target phosphatidylserine affect immune cells in people living with HIV on ART.
-
Ribosomal frameshifting in HIV-1 infection and its effects on inflammation and brain health
A study at the University of Rochester will explore how HIV-1 may change human cell machinery to boost its own replication and cause inflammation and brain-related problems.
-
Targeting NLRP3 inflammasome to protect HIV patients from stroke
A small NIH grant will explore whether HIV infection makes stroke worse and whether blocking a brain inflammation pathway (NLRP3) could protect brain tissue.
-
Reprogramming tissue immune cells (macrophages) to target hidden HIV
Trying small drug molecules to reprogram tissue immune cells so infected cells die and hidden HIV is reduced in people living with HIV.
-
EHD4 protein and HIV-1 infection: a new potential antiviral target
A study to understand how the human protein EHD4 affects HIV-1 infection and whether it could be targeted to develop better antiviral therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.