Condition

Coronary Microvascular Dysfunction clinical trials and research

• 13Clinical trials
• 13NIH research projects
• 12Countries

Newest Coronary Microvascular Dysfunction clinical trials

All recruiting trials (13)

• Coronary thrombus modification to reduce microvascular damage during STEMI care

  This study tests whether modifying the clot in the heart arteries during primary PCI can lessen microvascular damage and myocardial injury in STEMI patients.

  Recruiting Odense University Hospital · Odense · NCT07646977

• CS reducer device for symptomatic HFpEF with coronary microvascular dysfunction

  This study will test whether implanting a coronary sinus (CS) reducer reduces heart muscle ischemia on stress CMR in adults with HFpEF and coronary microvascular dysfunction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07093528

• Improving coronary blood flow in women with HIV and diabetes or chronic kidney disease

  This study will test whether referring women with HIV and diabetes or chronic kidney disease to a specialist so they can be considered for SGLT2 inhibitor medicine, compared with health education alone, improves blood flow in their hearts.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT06843902

• Measuring heart microvascular function in heart attack patients

  This study is testing how well the tiny blood vessels in the heart work in people who have had a heart attack to see how treatment affects their recovery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06795035

• Effects of Tirzepatide on Heart Health in Overweight Individuals

  This study tests if tirzepatide can improve heart health and reduce plaque in the arteries of overweight people with stable coronary artery disease.

  Recruiting at 2 sites Phase 4 Steno Diabetes Center Copenhagen · Copenhagen and 2 other locations · NCT06606821

• Registry of patients with angina undergoing coronary physiology testing

  This study collects information from adults with angina to see how well different tests for heart issues work and what happens to patients over time.

  Recruiting at 6 sites Institute for Cardiovascular Diseases Dedinje · Rijeka and 9 other locations · NCT06393478

• Evaluating the effects of esmolol in patients with heart attacks

  This study tests if giving esmolol early to people having a heart attack can help protect their heart and improve blood flow compared to those who don’t get the treatment.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT06376630

• Registry on coronary function testing in Belgium

  This study looks at how often doctors in Belgium use tests to check heart blood flow and related issues in patients, while also gathering information about their symptoms and quality of life.

  Recruiting at 13 sites University Hospital, Antwerp · Deurne, Antwerp and 12 other locations · NCT06089031

• Impact of Bivalirudin on Coronary Microcirculation During PCI

  This study is testing if using bivalirudin instead of standard heparin during heart procedures can help people with coronary heart disease have better blood flow in their tiny heart vessels and improve their long-term health.

  Recruiting Phase 4 Peking University First Hospital · Beijing, Beijing Municipality · NCT05984537

• Registry for patients with coronary microvascular disease

  This study is creating a database to collect information from people with coronary microvascular disease to help researchers learn more about the condition and improve treatments.

  Recruiting at 3 sites Medstar Health Research Institute · Washington D.C., District of Columbia and 2 other locations · NCT05960474

• Understanding how heart conditions affect tolerance to rapid heart rates

  This study is testing how well people with heart conditions, especially those with coronary artery disease, can handle fast heart rates and whether treating their condition with stents can help them tolerate it better.

  Recruiting Imperial College London · London · NCT05841199

• Assessing coronary microvascular dysfunction in heart attacks without blocked arteries

  This study is trying to see how problems with small blood vessels in the heart affect people who have heart attacks but don’t have blocked arteries.

  Recruiting Chonnam National University Hospital · Gwangju, Gwangju · NCT05272618

• Examining small vessel disease in women with heart issues

  This study is trying to see how small blood vessel problems in the heart affect women with heart issues who don't have blocked arteries, to help understand heart failure better.

  Recruiting at 2 sites Cedars-Sinai Medical Center · Los Angeles, California and 1 other locations · NCT03876223

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• LU-1001: a potential treatment for coronary tiny vessels dysfunction

  A small NIH grant is studying LU-1001 to help people with coronary microvascular dysfunction by better diagnosing and potentially treating problems in the heart’s tiny blood vessels.

  NIH research Lucier Pharmaceuticals INC · Cypress, United States · NIH-11409376

• Understanding how body composition and microvascular heart problems relate to cardiometabolic disease in women and men

  This NIH grant will use advanced imaging to study how obesity, coronary microvascular dysfunction, and HFpEF create different cardiometabolic heart disease profiles, with a focus on women.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11397686

• Quantitative Heart Scan to Find Coronary Microvascular Problems in Long COVID Patients

  A heart MRI study will look for tiny blood vessel problems in people who have long-lasting COVID symptoms and chest pain.

  NIH research Northwestern University · Chicago, United States · NIH-11377970

• Cardiac MRI to understand coronary microvascular dysfunction

  A heart-imaging project uses AI-enhanced MRI to better diagnose and monitor chest pain from small-vessel heart problems in patients without blocked arteries.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11345505

• How mental stress affects small coronary blood vessels in women

  This project looks at whether women with small-vessel heart disease have stronger stress-driven nerve responses that narrow heart microvessels and cause symptoms.

  NIH research Emory University · Atlanta, United States · NIH-11257272

• Understanding how mental stress affects heart function in women with coronary microvascular dysfunction

  This study is looking at how stress affects the heart in women with coronary microvascular dysfunction, hoping to learn more about how stress impacts heart health and find better ways to help manage their symptoms.

  NIH research Emory University · Atlanta, United States · NIH-11254974

• Fixing tiny heart blood vessel problems in diabetic heart disease

  This work tests whether restoring a small molecule called miR-21 can bring small coronary arteries back to healthy widening and improve heart blood flow in adults with diabetes-related heart disease.

  NIH research University of Arizona · Tucson, United States · NIH-11178607

• Understanding blood flow issues in diabetic heart disease

  This study looks at how diabetes can cause problems with the small blood vessels in the heart, which affects blood flow and heart health, and it aims to find new treatments that could help improve heart function for people with diabetes.

  NIH research University of Arizona · Tucson, United States · NIH-11172152

• Understanding Heart Fat Accumulation in Women with Small Heart Vessel Problems and Heart Failure

  This project aims to understand how fat buildup in the heart muscle contributes to a specific type of heart failure, especially in women with issues in their heart's tiny blood vessels.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11158866

• Understanding how mental stress affects blood flow in women with heart issues.

  This study is looking at how mental stress affects women who have heart symptoms but don’t have blocked arteries, specifically focusing on a condition called coronary microvascular dysfunction, and it aims to better understand how stress impacts heart health to help improve treatment options for these women.

  NIH research Emory University · Atlanta, United States · NIH-11009063

• Investigating heart fat accumulation in women with coronary microvascular dysfunction and its link to heart failure.

  This study is looking at how problems with small blood vessels in the heart can affect women and lead to heart failure, and it aims to find new ways to help improve heart health for those who are impacted.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10897016

• Understanding how coronary microvascular dysfunction can lead to heart failure in women.

  This study is looking into how problems with small blood vessels in the heart can lead to heart failure, especially in women, and it aims to find better treatments for those at risk due to factors like high blood pressure, obesity, and changes in estrogen levels.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10576287

• Investigating heart health risks in women with HIV

  This study is looking at why women over 50 with HIV might have a higher chance of heart attacks, and it aims to find out what causes heart problems in them compared to women without HIV, so we can help keep them healthier.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10453446

Related topics

Quick answers

How many Coronary Microvascular Dysfunction clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (5 trials), Denmark (2 trials), Croatia (1 trial), Greece (1 trial), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →