BEAT-HIV: Combination Treatments to Cure HIV-1 Infection
Official title: BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy
Funded at Wistar Institute · NIH-11080771 · Data updated 2026-11-12
This project looks for new ways to cure HIV-1 infection by combining different immune-boosting treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 16, 2021 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $5,626,081 |
| NIH project number | 5UM1AI164570-05 |
| Project ID | NIH-11080771 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients living with HIV-1 infection who are currently on antiretroviral therapy would be the primary focus for future clinical applications.
✕Less likely to help
Patients who do not have HIV-1 infection or those whose condition is not related to viral reservoirs may not directly benefit from this specific approach.
What this research studies
Current HIV treatments keep the virus in check but don't get rid of it completely, meaning the virus can return if treatment stops. This project hopes to achieve long-term control or even a cure for HIV by better understanding how the virus hides and how the body fights it. Researchers are developing new strategies, including special antibodies and immune cell therapies, to control the virus without daily medication. They are also working on combination therapies, including tiny nanoparticles, to completely remove the hidden virus from the body. This work involves studying patient samples, using advanced models, and planning for future clinical trials.
Why it matters
Potential benefit: If successful, this work could lead to long-term remission or a complete cure for HIV-1 infection, freeing patients from daily antiretroviral therapy.
How similar studies have gone: While current treatments effectively manage HIV, previous attempts to fully eradicate the virus have been insufficient, making this combination immunotherapy approach a novel and ambitious strategy.
Where this research is happening
-
Wistar Institute
Philadelphia, United States Active
Researchers
- Principal investigator: Montaner, Luis J — Wistar Institute
- Study coordinator: Montaner, Luis J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.