BEAT-HIV: Combination Treatments to Cure HIV-1 Infection
BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy
['FUNDING_OTHER'] · WISTAR INSTITUTE · NIH-11080771
This project looks for new ways to cure HIV-1 infection by combining different immune-boosting treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11080771 on ClinicalTrials.gov |
What this research studies
Current HIV treatments keep the virus in check but don't get rid of it completely, meaning the virus can return if treatment stops. This project hopes to achieve long-term control or even a cure for HIV by better understanding how the virus hides and how the body fights it. Researchers are developing new strategies, including special antibodies and immune cell therapies, to control the virus without daily medication. They are also working on combination therapies, including tiny nanoparticles, to completely remove the hidden virus from the body. This work involves studying patient samples, using advanced models, and planning for future clinical trials.
Who could benefit from this research
Good fit: Patients living with HIV-1 infection who are currently on antiretroviral therapy would be the primary focus for future clinical applications.
Not a fit: Patients who do not have HIV-1 infection or those whose condition is not related to viral reservoirs may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could lead to long-term remission or a complete cure for HIV-1 infection, freeing patients from daily antiretroviral therapy.
How similar studies have performed: While current treatments effectively manage HIV, previous attempts to fully eradicate the virus have been insufficient, making this combination immunotherapy approach a novel and ambitious strategy.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MONTANER, LUIS J — WISTAR INSTITUTE
- Study coordinator: MONTANER, LUIS J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus