Investigating how CARD8 inflammasome affects HIV-1 infection
Understand the role of CARD8 inflammasome in HIV-1 infection
This study is looking at how a part of your immune system called CARD8 interacts with the HIV virus and how this could help us find better ways to treat people living with HIV by targeting hidden virus reservoirs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11077212 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the CARD8 inflammasome in HIV-1 infection, particularly how it interacts with the virus and influences the immune response. The study aims to explore the mechanisms by which HIV-1 protease affects CARD8 activation, which could lead to new strategies for targeting latent HIV reservoirs in patients. By examining the relationship between the virus and the inflammasome, researchers hope to identify potential therapeutic approaches that could enhance the effectiveness of existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are currently on antiretroviral therapy and have not achieved a complete viral eradication.
Not a fit: Patients who are not infected with HIV-1 or those who have not responded to antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help eradicate HIV-1 from the body, improving outcomes for patients living with the virus.
How similar studies have performed: Other research has shown promise in targeting viral components for HIV treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Shan, Liang — Washington University
- Study coordinator: Shan, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.