Investigating how certain proteins interact with HIV-1 during early infection
+TIPs as novel host capsid-binding co-factors in early HIV-1 infection
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11017810
This study is looking at how certain proteins in our bodies interact with the HIV virus in its early stages, which could help scientists find new ways to treat HIV and improve care for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11017810 on ClinicalTrials.gov |
What this research studies
This research explores the early stages of HIV-1 infection, focusing on how specific host proteins interact with the virus's capsid, which is crucial for its stability and transport within the host cell. The study aims to identify and characterize these interactions using advanced techniques like cryo-electron microscopy. By understanding these mechanisms, researchers hope to uncover new targets for therapeutic intervention that could disrupt the viral life cycle. Patients may benefit from insights that could lead to innovative treatments for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of HIV infection or those in the early stages of HIV infection.
Not a fit: Patients with chronic HIV infection or those who are already on antiretroviral therapy may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating HIV infection.
How similar studies have performed: Previous research has shown promise in targeting host-virus interactions, suggesting that this approach could yield significant advancements in HIV treatment.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAGHAVI, MOJGAN HOSSEINI — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: NAGHAVI, MOJGAN HOSSEINI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.