Investigating how HIV-1 infection and antiretroviral therapy affect brain function
The effects of cART and HIV-1 infection on neural circuitry
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11010369
This study is looking at how HIV-1 infection and the treatment for it can affect thinking and memory by using special imaging techniques on mice to see how their brains work, which could help us understand similar challenges in people living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11010369 on ClinicalTrials.gov |
What this research studies
This research explores the impact of HIV-1 infection and antiretroviral therapy (ART) on cognitive function by examining changes in brain circuitry. Using advanced 3D imaging techniques, the study aims to create detailed maps of neuronal activation in mice to identify how these factors influence brain activity. The researchers will analyze the effects of prolonged ART and HIV-1 infection on neural pathways, particularly in relation to cognitive challenges. This approach may help uncover the underlying mechanisms of cognitive deficits observed in individuals undergoing ART.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV-1 who are undergoing antiretroviral therapy.
Not a fit: Patients who are not infected with HIV-1 and are not using antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cognitive impairments in individuals with HIV-1.
How similar studies have performed: Previous research has shown that understanding neural circuitry can lead to significant advancements in treating cognitive deficits, suggesting this approach has potential for success.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ENIKOLOPOV, GRIGORI N — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: ENIKOLOPOV, GRIGORI N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus