How HIV-1 infects CD4+ T cells through a process called macropinocytosis
Roles of Macropinocytosis in HIV-1 infection of CD4+ T Cells
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11109483
This study is looking at how HIV-1 gets into important immune cells called CD4+ T cells and how a special process called macropinocytosis helps with this, so we can find new ways to fight HIV/AIDS.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11109483 on ClinicalTrials.gov |
What this research studies
This research investigates the role of macropinocytosis, a unique cellular process, in how HIV-1 infects CD4+ T cells, which are crucial for the immune response. The team aims to understand the specific mechanisms of HIV-1 entry into these cells, focusing on how this process differs from previously studied methods. By examining the effects of inhibiting macropinocytosis, the researchers hope to uncover new insights into HIV-1 infection and its impact on immune function. This could lead to novel therapeutic strategies to combat HIV/AIDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS, particularly those with active CD4+ T cell involvement.
Not a fit: Patients who are not infected with HIV or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent HIV-1 from infecting immune cells, potentially improving outcomes for patients with HIV/AIDS.
How similar studies have performed: While the specific focus on macropinocytosis in HIV-1 infection is relatively novel, other studies have successfully explored alternative entry mechanisms for viruses, indicating potential for impactful findings.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ONO, AKIRA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: ONO, AKIRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus