Understanding how antibodies interact with the gut microbiome in HIV-1 infection
Official title: The Public Mucosal Antibody Repertoire in HIV-1 Infection
Funded at University of Colorado Denver · NIH-10918746 · Data updated 2026-11-12
This study is looking at how a type of antibody called IgA helps keep the gut healthy for people living with HIV-1, by comparing gut samples from those with and without the virus to see how these antibodies work with gut bacteria and affect overall health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $210,600 |
| NIH project number | 1R21AI183981-01 |
| Project ID | NIH-10918746 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who are currently on antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV-1 or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the role of antibodies, specifically IgA, in maintaining gut health for individuals living with HIV-1. By analyzing gut biopsies from both HIV-1 positive and negative individuals, the study aims to identify how these antibodies interact with the gut microbiome and contribute to gut homeostasis. The researchers will utilize advanced sequencing techniques to explore the diversity of the antibody repertoire and its implications for inflammation and overall health in HIV-1 patients. This work could lead to new therapeutic strategies to improve gut integrity and reduce associated health risks.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance gut health and reduce inflammation-related illnesses in people living with HIV-1.
How similar studies have gone: While the concept of public antibodies is emerging, this specific approach to studying their role in HIV-1 infection and gut health is relatively novel and has not been extensively tested in humans.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Santiago, Mario Luis — University of Colorado Denver
- Study coordinator: Santiago, Mario Luis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.