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Clinical trial Recruiting at 1 site Observational Ages 18 and up

Investigating the HIV Infected Reservoir to Find a Cure

Official title: Ex Vivo Characterization and Targeting of the Latent HIV Infected Reservoir to Cure HIV

Run by Erasmus Medical Center · NCT05215704 · Data updated 2026-11-12

This study is trying to find ways to cure HIV by looking at the hidden virus in the blood of different groups of people living with HIV.

More HIV Infections trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment40 (estimated)
SponsorErasmus Medical Center
Academic / other
Drugs / interventionscART
Locations1 site (Rotterdam)
StatusRecruiting
StartedJanuary 1, 2012
Main results expectedDecember 31, 2030
Study endsDecember 31, 2030
Registry record updatedFebruary 14, 2024
Trial IDNCT05215704 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults aged 18 and older with confirmed HIV-1 or HIV-2 infections.

Probably not a fit

Patients with major comorbidities or those unable to undergo necessary blood sampling may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize and target the latent HIV infected reservoir in patients to explore potential strategies for curing HIV. It involves collecting peripheral blood mononuclear cells and whole blood from HIV-infected individuals to assess the impact of latency disruptors on the reservoir. The study will include various patient groups, such as those with HIV-1 and HIV-2 infections, long-term non-progressors, elite controllers, and post-treatment controllers. Participants may also consent to longitudinal follow-up for up to four years to gather additional data.

Why it matters

Potential benefit: If successful, this study could lead to effective strategies for eradicating HIV from the body.

How similar studies have gone: Other studies have explored similar approaches to targeting the HIV reservoir, but this specific methodology is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age 18 years or older.
2. Confirmed HIV-1 or HIV-2 infection.

Exclusion Criteria:

1. Inability to place 2.5 cm venous catheter or perform phlebotomy
2. Major comorbidities:

   A. Severe symptomatic anemia B. Recent symptomatic cardiovascular event (unstable angina pectoris, decompensated heart failure, myocardial infarction).
3. The inability to participate due to any other relevant medical, social, environmental, psychological, factors or according to the HIV treating physician's judgement

Where it's running

  • Erasmus Medical Centre
    Rotterdam, Netherlands     Recruiting

Study contacts

  • Principal investigator: Casper Rokx, MD PhD — Erasmus Medical Center
  • Study coordinator: Casper Rokx, MD PhD
  • Email: c.rokx@erasmusmc.nl

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.