Understanding heart failure in people with HIV-1 infection
Official title: Diastolic Heart Failure in HIV-1 infection
Funded at University of Nebraska Medical Center · NIH-10875565 · Data updated 2026-11-12
This study is looking at how a harmful substance in the body might lead to heart problems in people with long-term HIV, and it hopes to find new ways to help treat these heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $612,681 |
| NIH project number | 5R01HL164306-03 |
| Project ID | NIH-10875565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with chronic HIV-1 infection who are experiencing symptoms of heart failure.
✕Less likely to help
Patients who do not have HIV-1 infection or those without symptoms of heart failure may not benefit from this research.
What this research studies
This research investigates the causes of diastolic heart failure (dHF) in individuals living with chronic HIV-1 infection. It aims to explore how elevated levels of a toxic metabolite called methylglyoxal (MG) contribute to the development of dHF. The study will utilize humanized mice to define the biological pathways involved and assess the impact of antiretroviral drugs on these mechanisms. By understanding these processes, the research seeks to identify potential treatment strategies for dHF in this population.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for heart failure in patients with HIV-1, improving their overall health and quality of life.
How similar studies have gone: While the specific approach of this research is novel, previous studies have indicated that understanding metabolic changes in HIV-infected individuals can lead to significant advancements in treatment.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Bidasee, Keshore R — University of Nebraska Medical Center
- Study coordinator: Bidasee, Keshore R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.