Investigating how different injectable contraceptives affect HIV-1 infection risk in women.
Biological effects, hormone levels and mechanisms relevant to HIV-1 infection for women randomized to the injectable contraceptives depo-medroxyprogesterone acetate or norethisterone enanthate.
['FUNDING_R01'] · UNIVERSITY OF CAPE TOWN · NIH-10815728
This study is looking at how two types of birth control shots might affect the risk of getting HIV-1 in young women in sub-Saharan Africa, so we can better understand their safety and help keep women healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CAPE TOWN (nih funded) |
| Locations | 1 site (RONDEBOSCH, SOUTH AFRICA) |
| Trial ID | NIH-10815728 on ClinicalTrials.gov |
What this research studies
This research explores the biological mechanisms by which injectable contraceptives may influence susceptibility to HIV-1 infection, particularly among young women in sub-Saharan Africa. It compares two commonly used contraceptives: depo-medroxyprogesterone acetate (DMPA-IM) and norethisterone enanthate (NET-EN). The study aims to gather observational data to understand the potential increased risk of HIV-1 associated with these contraceptives, especially given the high prevalence of HIV-1 in this demographic. Participants will be monitored to assess hormone levels and other biological factors that may contribute to infection risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are young women in sub-Saharan Africa who are using or considering injectable contraceptives.
Not a fit: Patients who are not using injectable contraceptives or who are not at risk for HIV-1 infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer contraceptive options for women, reducing their risk of HIV-1 infection.
How similar studies have performed: Previous studies have indicated varying risks associated with different injectable contraceptives, suggesting that this research could build on existing findings.
Where this research is happening
RONDEBOSCH, SOUTH AFRICA
- UNIVERSITY OF CAPE TOWN — RONDEBOSCH, SOUTH AFRICA (ACTIVE)
Researchers
- Principal investigator: HAPGOOD, JANET PATRICIA — UNIVERSITY OF CAPE TOWN
- Study coordinator: HAPGOOD, JANET PATRICIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.